Eluxadoline
Indications
Eluxadoline is indicated in adults for the treatment of irritable bowel syndrome with diarrhea (IBS-D).
Pharmacology
Eluxadoline is a mu-opioid receptor agonist, kappa opioid receptor agonist & delta opioid receptor antagonist. Eluxadoline works directly in intestine to reduce peristalsis, also makes the nerves in intestine less sensitive to stimulation.
Dosage & Administration
The recommended dosage in adults is 100 mg twice daily taken with food.
The recommended dosage is 75 mg twice daily taken with food in patients who:
If a dose is missed, take the next dose at the regular time; do not take 2 doses at once
The recommended dosage is 75 mg twice daily taken with food in patients who:
- are unable to tolerate the 100 mg dose.
- are receiving concomitant OATP1B1 inhibitors.
- have mild or moderate hepatic impairment.
If a dose is missed, take the next dose at the regular time; do not take 2 doses at once
Interaction
Oral Contraceptive, Cyclosporine, Probenecid, Rosuvastatin.
Contraindications
Known or suspected biliary duct obstruction, sphincter of oddi disease or dysfunction & pancreatitis.
Side Effects
Most common adverse reactions are constipation, nausea and
abdominal pain.
abdominal pain.
Pregnancy & Lactation
Pregnancy: Not established.
Lactation: Not established.
Lactation: Not established.
Precautions & Warnings
Sphincter of Oddi spasm and Pancreatitis.
Patients who should be monitored closely-
Patients who should be monitored closely-
- without a gallbladder
- with new or worsening abdominal pain
- with nausea and vomiting
- with acute biliary pain
- with liver or pancreatic enzyme elevation
Use in Special Populations
Pediatric Use: Safety and effectiveness in pediatric patients have not been established.
Hepatic Impairment: It is contraindicated in patients with severe hepatic impairment.
Hepatic Impairment: It is contraindicated in patients with severe hepatic impairment.
Therapeutic Class
Carboxylic acids and derivatives, Prokinetic drugs
Storage Conditions
Store in a cool & dry place, protect from light. Keep out of the reach of children.
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