Methoxsalen
Indications
Repigmentation of vitiliginous areas, Psoriasis, Repigmentation of vitiliginous areas
Pharmacology
Methoxsalen increases skin reactivity to long-wavelength UV rays. It bonds covalently to deoxyribonucleic acid (DNA), thus inhibiting DNA synthesis and suppressing cell division and epidermal turnover. This effect is used in photochemotherapy or PUVA [psoralen (P) and high-intensity long-wavelength UVA irradiation].
Dosage
Topical-
Adult use:- Repigmentation of vitiliginous areas: As 1% soln (diluted to 0.1-0.01%): Apply over lesions then expose to UVA immediately after application or wait up to 2 hr. Protect the area surrounding the lesion with a sunscreen. Wash and protect lesions from light after treatment; protection may be up to ≥48 hr. Treatment is usually repeated once wkly. Substantial repigmentation usually requires 6-9 mth of treatment.
- Psoriasis: As a 0.15% soln (diluted to 0.015%, if necessary): Apply to affected areas 15 min before UVA exposure. Alternatively, patient may take a whole body bath in methoxsalen soln for 15 min followed by immediate UVA exposure. For treating affected areas, immerse the affected areas for 15 min into 3 mg/L soln of hand and foot soaks followed by a 30-min delay before UVA exposure. Baths or soaks are given twice wkly.
Pediatric use (Children ≥12 years): Vitiligo: Refer to adult dosing.
Oral (Adult)-
Repigmentation of vitiliginous areas: 20 mg or up to 600 mcg/kg 2-4 hr before measured periods of UVA exposure depending on the preparation, given twice wkly or on alternate days, with at least 48-hr intervals.Psoriasis: Up to approx 600 mcg/kg, given 1.5-3 hr before UVA exposure, depending on the preparation. Treatment is usually given twice wkly or increased as necessary, with at least 48-hr intervals between doses. If there is no or minimal response after the 15th PUVA treatment, dose may be increased by 10 mg and this dose used for the remainder of the treatment course.
Administration
Hands and fingers of person applying the lotion should be protected to prevent possible photosensitization and/or burns.
Interaction
May increase plasma concentration of drugs metabolised by CYP2A6 isoenzyme. Additive effect with other systemic or topical photosensitising agents (e.g. anthralin, coal tar, nalidixic acid).
Contraindications
Aphakia, existing or history of melanoma, invasive squamous cell carcinoma, photosensitivity diseases (e.g. porphyria, acute lupus erythematosus, xeroderma pigmentosum).
Side Effects
Major Side Effects are-
Premature aging of the skin may occur as a result of prolonged methoxsalen therapy. This effect is permanent and is similar to the result of sunbathing for long periods of time.
- Blistering and peeling of skin
- reddened, sore skin
- swelling, especially of the feet or lower legs
Premature aging of the skin may occur as a result of prolonged methoxsalen therapy. This effect is permanent and is similar to the result of sunbathing for long periods of time.
Pregnancy & Lactation
Methoxsalen lotion has been assigned to pregnancy category C by the FDA. Animal reproduction studies have not been conducted with topical methoxsalen, although it has been shown to be a potent photocarcinogen in certain strains of mice. There are no controlled data in human pregnancy. It is also not known to what extent, if any, methoxsalen is absorbed systemically following topical administration. Methoxsalen lotion is only recommended for use during pregnancy when benefit outweighs risk.
Precautions & Warnings
Patient exhibiting multiple basal cell carcinoma or history of basal cell carcinoma, previous arsenic therapy, previous x-ray or grenz ray therapy; cardiac diseases or those unable to tolerate prolonged standing or exposure to heat stress; GI diseases or chronic infection. Hepatic impairment. Pregnancy and lactation.
Therapeutic Class
Methoxsalen preparation
Storage Conditions
Store between 15-30° C. Protect from light.
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