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Idoxuridine

Indications

Idoxuridine Eye drops is used for Skin infection, Eyes infection, Infection of reproduction organs, Herpes simplex infections of skin, External reproductive organs infection, External eyes area infection and other conditions. Idoxuridine Eye drops may also be used for purposes not listed in this medication guide.

Pharmacology

Herpes simplex virus utilizes thymidine in the synthesis of deoxyribonucleic acid (DNA), a metabolite necessary for reproduction. Idoxuridine is identical in chemical structure to thymidine except that the 5-methyl group is replaced by iodine. When idoxuridine is substituted for thymidine in DNA, the cell is unable to utilize the DNA and reproduction ceases.

Dosage & Administration

Herpes simplex keratitis: As 0.1% solution: Instill 1 drop in the affected eye(s) every hour. Taper to every 2 hr or 4 times daily. Continue treatment for at least 7 days.

Interaction

Corticosteroids may accelerate spread of viral infection.

Contraindications

Contraindicated in hypersensitivity to any ingredient of this preparation.

Side Effects

Common side effects are eye irritation or pain, redness, itching, swelling of the eye, increased sensitivity to light and glare

Pregnancy & Lactation

Idoxuridine should be administered with caution in pregnancy or in women of childbearing potential. Idoxuridine has been reported to cross the placental barrier and to produce fetal malformations in rabbits when administered topically to the eyes of pregnant females in doses similar to those used clinically.

Precautions & Warnings

For topical use only. Do not exceed the frequency or duration of recommended dosage. The incidence of some adverse reactions increases with prolonged use. Idoxuridine is not effective in corneal inflammations following herpes simplex keratitis in which the virus is not present. Some strains of herpes simplex appear resistant to the action of Idoxuridine.

Therapeutic Class

Ophthalmic Anti-viral Products

Storage Conditions

Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children.

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