Alcaftadine
Indications
Alcaftadine eye drops is indicated for the
prevention of itching associated with allergic conjunctivitis.
Alcaftadine ophthalmic solution is an H1 receptor antagonist, in a
sterile ophthalmic solution for topical ophthalmic use.
Pharmacology
This eye drops is a sterile topical
ophthalmic solution containing Alcaftadine. Alcaftadine is an histamine
receptor antagonist and inhibitor of the release of histamine from mast
cell. It is also a potent histamine H2 and H4 receptor antagonist that
has demonstrated anti-inflammatory property. In doing so, antihistaminic
effect provides relief from itching associated with early phase of
ocular allergic response, whereas mast cell stabilization inhibits the
release of mediators such as cytokines and lipid mediators that play a
role in late-phase response of allergic conjunctivitis.
Dosage & Administration
Adults and children 2 years and over: Instill one drop in each eye once daily.
Contraindications
Alcaftadine is contraindicated in patients with hypersensitivity to any component in the product.
Side Effects
The most frequent ocular reactions are eye
irritation, burning or/and stinging upon instillation, eye redness and
eye pruritus, nasopharyngitis and headache.
Pregnancy & Lactation
Pregnancy category B. There are however, no
adequate and well controlled studies in pregnant women, thus this drug
should be used during pregnancy only if clearly needed. It is not known
whether this drug is excreted in human milk. Caution should be exercised
while administered to a nursing woman.
Precautions & Warnings
To minimize eye injury and contamination of
the dropper tip and solution, care should be taken not to touch the
eyelids or surrounding areas with the dropper tip of the bottle.
Patients should be advised not to wear a contact lens if their eye is
red. This preparation should not be used to treat contact lens related
irritation and should not be instilled while wearing contact lenses.
Remove contact lenses prior to instillation this preparation. Lenses may
be reinserted after 10 minutes following administration. If more than 1
topical ophthalmic medicinal product is being used, each one should be
administered at least 5 minutes apart.
Use in Special Populations
Pediatric Use: Safety and effectiveness in pediatric patients below the age of 2 years have not been established.
Geriatric Use: No overall differences in safety or effectiveness were observed between elderly and younger subjects.
Therapeutic Class
Ophthalmic Anti-allergic preparations
Storage Conditions
Store in a cool (15°C - 25°C) and dry place protected from light. Do not use after one month once the cap is opened.
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