Allylestrenol
Indications
Allylestrenol is indicated in:
- Intra Uterine Growth Retardation (IUGR)
- Threatened abortion
- Habitual abortion
- Threatened premature delivery
Pharmacology
Allylestrenol is a synthetic progesterone
derivative that is used to treat threatened pregnancies. It can stop
occurring premature labor and can help women give birth to a healthy
newborn. It stimulates the secretory phase in myometrium, creates
conditions for development of fertilized ovum. It has a tocolytic
effect; reduces sensitivity of myometrium to oxytocin. It stimulates the
development of acinus of mammary glands, secretory activity of
trophoblasts, and development of aldosterone by adrenal glands.
Allylestrenol also has a selection of β-adrenergic effect. In
this way, it stimulates the synthesis of the body's placental
progesterone, therefore increasing the secretion of placental hormones.
Dosage & Administration
Intra Uterine Growth Retardation: 1 tablet three times a day at least two months. Dose to be reduced if symptoms improve.
Threatened abortion: 1 tablet three times daily until symptoms disappear.
Habitual abortion: 1-2 tablets daily as soon as pregnancy is diagnosed. The administration should be continued for at least one month after the end of the critical period.
Threatened premature delivery: Dosage must be determined individually. High dosages (up to 40 mg daily) have been used.
In case of a missed dose, it should be taken as soon as the patient remembers & she should continue the regular dosing schedule. A double dose is not recommended.
Threatened abortion: 1 tablet three times daily until symptoms disappear.
Habitual abortion: 1-2 tablets daily as soon as pregnancy is diagnosed. The administration should be continued for at least one month after the end of the critical period.
Threatened premature delivery: Dosage must be determined individually. High dosages (up to 40 mg daily) have been used.
In case of a missed dose, it should be taken as soon as the patient remembers & she should continue the regular dosing schedule. A double dose is not recommended.
Contraindications
Hypersensitivity; thrombophlebitis;
undiagnosed vaginal bleeding, incomplete abortion, hormone-dependent
carcinoma, cerebral apoplexy, as a diagnostic test for pregnancy; severe
hepatic impairment.
Side Effects
Treatment with Allylestrenol (especially a
long term treatment) is known to cause some gastrointestinal complaints
such as vomiting, nausea, and sometimes epigastric discomfort.
Pregnancy & Lactation
Allylestrenol is specifically designed to
be taken during pregnancy. It should be discontinued after delivery as
it may affect a nursing infant to a small but noticeable degree.
Precautions & Warnings
Patients with the following conditions
should be cautious: Heart disease, congestive heart failure, sick sinus
syndrome, coronary artery disease, seizures, epilepsy, renal
dysfunction, migraine headaches, or breathing diseases including asthma,
emphysema, chronic bronchitis, or COPD, breast-feeding.
Use in Special Populations
It should not be used for children younger than 16 years old.
Overdose Effects
Symptoms of overdose may include unusual
drowsiness; rapid pulse; fainting; unusual muscle movement or rigidity
of the face, neck, or limbs; seizures; and loss of consciousness.
Therapeutic Class
Female Sex hormones
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
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