Betacarotene + Vitamin C + Vitamin E
Indications
Antioxidant vitamins are used in a wide
range of conditions where free radical damage is playing a role.
Antioxidant vitamin combination is used in the prevention of coronary
heart diseases, certain types of cancer, aging as well as free radical
damage caused by excessive exercise, illness, certain medications, air
pollution, smoke, radiation and pesticides. The main role of the
antioxidant vitamins is as follows:
β carotene prevents free radical formation by quenching singlet oxygen, a highly reactive form of oxygen. Vitamin C is another free radical scavenger which deactivates free radicals. It works specially in the plasma, lung fluid, aqueous humour and interstitial fluid. It can increase white blood cell activity; play important roles in the biochemistry of antibodies, prostaglandin E 1 , B and T lymphocytes, and interferon. Vitamin E also scavenges free radicals in the blood along with β carotene and vitamin C. Moreover, vitamin E is essential to protect against some of the ill effects of smog and smoke. In relation to other nutrients vitamin E protects vitamin A from being destroyed in the body.
β carotene prevents free radical formation by quenching singlet oxygen, a highly reactive form of oxygen. Vitamin C is another free radical scavenger which deactivates free radicals. It works specially in the plasma, lung fluid, aqueous humour and interstitial fluid. It can increase white blood cell activity; play important roles in the biochemistry of antibodies, prostaglandin E 1 , B and T lymphocytes, and interferon. Vitamin E also scavenges free radicals in the blood along with β carotene and vitamin C. Moreover, vitamin E is essential to protect against some of the ill effects of smog and smoke. In relation to other nutrients vitamin E protects vitamin A from being destroyed in the body.
Pharmacology
Beta carotene of
this tablet is converted to vitamin A (Retinol) when required. Retinol
has several biochemical functions e.g. on retina, growth, tissue
differentiation, immunological response. It has also some anti-cancer
activity.
Vitamin C is the most powerful reducing agent known to be present in living tissues. Vitamin C deficiency produces scurvy. It is a cofactor in numerous biological processes. Vitamin C and molecular oxygen are essential for the conversion of proline to hydroxyproline, dopamine to noradrenaline . Vitamin C is also essential for the synthesis of adrenal steroid hormones. Vitamin C is important in the defense against infection and studies shown that vitamin C is important for the normal functioning of T-lymphocyte and leukocyte. Ascorbic acid has some antiinflammatory activity and protects cells against oxidation of essential molecules. In high doses, (1-2 g daily) ascorbic acid increases iron absorption.
vitamin E seems to be as a defense against oxidative stress and lipid peroxidation. In most cell membranes there is one molecule of tocopherol for every 1000 lipid molecules. Tocopherol mops up peroxide radicals and then needs a supply of reduced hydrogen to restore the steady-state situation. This is usually supplied by ascorbic acid or reduced glutathione.
Vitamin C is the most powerful reducing agent known to be present in living tissues. Vitamin C deficiency produces scurvy. It is a cofactor in numerous biological processes. Vitamin C and molecular oxygen are essential for the conversion of proline to hydroxyproline, dopamine to noradrenaline . Vitamin C is also essential for the synthesis of adrenal steroid hormones. Vitamin C is important in the defense against infection and studies shown that vitamin C is important for the normal functioning of T-lymphocyte and leukocyte. Ascorbic acid has some antiinflammatory activity and protects cells against oxidation of essential molecules. In high doses, (1-2 g daily) ascorbic acid increases iron absorption.
vitamin E seems to be as a defense against oxidative stress and lipid peroxidation. In most cell membranes there is one molecule of tocopherol for every 1000 lipid molecules. Tocopherol mops up peroxide radicals and then needs a supply of reduced hydrogen to restore the steady-state situation. This is usually supplied by ascorbic acid or reduced glutathione.
Dosage & Administration
This tablet is administered orally. The
adult dose of this combination of antioxidant vitamin tablet is 1 tablet
daily or as prescribed by the physician.
Interaction
Cholestyramine, Colestipol, Neomycin cause
decreased absorption of β carotene. Circulating vitamin C levels have
been shown to be reduced during prolonged administration of oral
contraceptives containing Oestrogen, Tetracycline and Aspirin. The
decrease in vitamin C level may be due to drug induced impaired
absorption or increased utilization of the vitamin for drug metabolism.
Vitamin E may enhance the anticoagulant activity of anticoagulant drugs.
High doses of vitamin E can impair intestinal absorption of vitamins A
and K.
Contraindications
Carocet is contraindicated in patients with hypersensitivity to any of its components.
Side Effects
β carotene is
comparatively safe even at high and prolonged exposure. Individuals who
routinely ingest large amounts of carotenoids can develop
hypercarotenosis, which is characterised by a yellowish colouration of
the skin and a very high concentration of carotenoids in the plasma.
This benign condition, although resembling jaundice, gradually
disappears upon correcting the excessive intake of carotenoids.
Vitamin C is generally a safe drug for human use in normal doses. Larger doses may lead to gastrointestinal tract upset and renal stone formation.
Vitamin E is considered safe even in large doses. Doses over 800 mg may cause diarrhoea, abdominal pain or cramps, fatigue and reduced resistance to bacterial infection and transiently raised blood pressure.
Vitamin C is generally a safe drug for human use in normal doses. Larger doses may lead to gastrointestinal tract upset and renal stone formation.
Vitamin E is considered safe even in large doses. Doses over 800 mg may cause diarrhoea, abdominal pain or cramps, fatigue and reduced resistance to bacterial infection and transiently raised blood pressure.
Pregnancy & Lactation
β carotene, vitamin C and vitamin E have no
teratogenic effects in humans. However, like any other drugs caution
should be taken in prescribing to pregnant women.
Precautions & Warnings
There are some evidences that β carotene
may cause harm to heavy smokers and alcoholics. Therefore, caution
should be exercised in these cases. Vitamin C should be given with
caution to patients with hyperoxaluria. Vitamin E should be used with
caution in patients taking anticoagulant drugs, because vitamin E may
enhance the anticoagulant activity of these drugs.
Therapeutic Class
Anti-oxidant Multivitamin preparations
Storage Conditions
Should be stored in a dry place below 30˚C.
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