Bisoprolol Hemifumarate
Indications
Bisoprolol is indicatedin-
- Hypertension
- Angina
- Moderate to severe heart failure
Pharmacology
Bisoprolol Hemifumarate is the most
selective ß1 blocker. It displays highest level of affinity for the ß1
receptor than any other beta-blocker available up to now. Selectively
blocks ß1 adrenergic receptor in the heart and vascular smooth muscle
and reduces heart rate and cardiac output resulting in decrease of
arterial hypertension. Lipid metabolism can be adversely affected by
ß-blockers, in patients with non-ß1 selective ß1-blocker, but Bisoprolol
does not cause any change in the cholesterol fraction including the
cardioprotective HDL-cholesterol, in long-term therapy.
Dosage & Administration
Hypertension: The dose of
Bisoprolol must be individualized to the needs of the patient. The usual
starting dose is 5 mg once daily. In some patients, 2.5 mg may be an
appropriate starting dose. If the antihypertensive effect of 5 mg is
inadequate, the dose may be increased to 10 mg and then, if necessary,
to 20 mg once daily.
Angina: Usually 10 mg once daily (5 mg may be adequate in some patients) max 20 mg daily.
Heart Failure: Initially 1.25 mg once daily (in the morning) for 1 week then, if well tolerated, increased to 2.5 mg once daily for 1 week, then 3.75 mg once daily for 1 week, then 5 mg once daily for 4 weeks, then- 7.5 mg once daily for 4 weeks, then 10 mg once daily maximum 10 mg daily.
Angina: Usually 10 mg once daily (5 mg may be adequate in some patients) max 20 mg daily.
Heart Failure: Initially 1.25 mg once daily (in the morning) for 1 week then, if well tolerated, increased to 2.5 mg once daily for 1 week, then 3.75 mg once daily for 1 week, then 5 mg once daily for 4 weeks, then- 7.5 mg once daily for 4 weeks, then 10 mg once daily maximum 10 mg daily.
Interaction
Bisoprolol should not be combined with other ß-blocking agents.
Contraindications
In patients with cardiogenic shock, overt
heart failure, second or third degree A-V block, right ventricular
failure secondary to pulmonary hypertension and sinus bradycardia.
Side Effects
Gastro-intestinal disturbances,
bradycardia, hypotension, headache, fatigue, sleep disturbances,
dizziness, vertigo, thrombocytopenia, visual disturbances, alopecia may
be occurred.
Pregnancy & Lactation
The safety of bisoprolol during pregnancy has not been established. No data is available for lactation.
Precautions & Warnings
Monitoring of renal, hepatic and
hematopoietic function should be performed at regular intervals during
long-term treatment with bisoprolol.
Therapeutic Class
Anti adrenergic agent (Beta blockers), Beta-adrenoceptor blocking drugs, Beta-blockers
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.