Bromhexine Hydrochloride

Indications

Bromhexine is indicated in the treatment of respiratory tract disorders associated with productive cough. This include-

Tracheobronchitis
Bronchitis with emphysema
Bronchiectasis
Bronchitis with bronchospasm
Chronic inflammatory pulmonary conditions and
Pneumoconiosis.

Pharmacology

Bromhexine Hydrochloride is an oral mucolytic agent. It disrupts the structure of acid mucopolysaccharide fibres in mucoid sputum and produces less viscous mucus, which makes easier the expectoration. It is rapidly & completely absorbed from the gastrointestinal tract. It is widely distributed into the body tissues.

Dosage & Administration

The recommended doses for adults and children are stated below:

Adult & Children over 12 years: 10 ml (2 teaspoons) 3 times daily
Children 6-12 years: 5 ml (1 teaspoon) 3 times daily
Children 2-6 years: 2.5 ml (1/2 teaspoon) 3 times daily
Bromhexine Hydrochloride is not recommended for children under 2 years of age without advice.

Interaction

There are no known significant interactions with other drugs.

Contraindications

It is contraindicated in known hypersensitivity to Bromhexine Hydrochloride or any of the ingredients of this product.

Side Effects

Gastrointestinal side effects may occur occasionally. A transient rise in serum aminotransferase values has been reported. Other reported side effects include-headache, vertigo (dizziness) and allergic reactions.

Pregnancy & Lactation

Use in Pregnancy: Special care is recommended during pregnancy. The benefits of bromhexine must be assessed against possible effects on children.

Use in Lactation: Bromhexine is expected to enter breast milk. Therefore it is not recommended that bromhexine be taken by lactating mothers.

Precautions & Warnings

Since mucolytics may disrupt the gastric mucosa bromhexine should be used with care in patients with a history of peptic ulcer disease. Care is also advisable in asthmatic patients. Clearance of bromhexine and its metabolites may be reduced in patients with severe hepatic or renal impairment.

Therapeutic Class

Cough expectorants & mucolytics

Storage Conditions

Keep in a dry place away from light and heat. Keep out of reach of children.

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