Calcium Dobesilate
Indications
Calcium Dobesilate is indicated for the
treatment of hemorrhoidal syndrome, microcirculation disorders of
arteovenous origin, clinical signs of chronic venous insufficiency in
the lower limbs (pain, cramps, paresthesia, edema, stasis, dermotosis)
and in the particular microangiopathy like diabetic retinopathy. It is
also indicated in superficial thrombophlebitis as adjuvant therapy.
Description
Calcium Dobesilate is a vasoactive drug
that presumes effects on endothelial integrity, capillary permeability
and blood viscosity. It decreases capillary hyperpermeability, decreases
platelet aggregation (clotting - adhesion of platelets) and reduces the
serum viscosity, which improves blood circulation and blood supply to
tissues and organs.
Pharmacology
Calcium dobesilate acts selectively on the
capillary walls regulating their physiological functions of resistance
and permeability. It lowers blood viscosity and restores normal blood
flow. This action is beneficial in all cases of capillary fragility due
to metabolic disturbances (constitutional or acquired), and surgical
stress or induced by certain medicines.
Dosage & Administration
Calcium Dobesilate capsule once or twice
daily should be taken with the main meal. Treatment duration, which
generally between a few weeks to several months, depends on the disease
and its evolution. Dosage should be adapted individually according to
the severity of the disease.
Contraindications
Hypersensitivity. Pregnancy and lactation.
Side Effects
Rarely gastrointestinal disorders including
nausea and diarrhea, skin reactions, fever, articular pain and in very
rare cases agranulocytosis have been reported. These reactions are
generally spontaneously reversible after treatment withdrawal.
Pregnancy & Lactation
The safety of Calcium Dobesilate during
pregnancy and lactation has not been established. As it is not known
whether calcium dobesilate crosses the placental barrier in humans, the
drug should be administered during pregnancy only if the benefit to the
mother outweighs the potential risk to the fetus. Avoid breastfeeding
while using this medicine.
Precautions & Warnings
Dosage should be reduced in case of severe
renal insufficiency requiring dialysis. In patient with agranulocytosis,
this medication can decrease the number of white blood cells which
affect the body’s ability to fight against various infections. If
patients experience flu-like symptoms such as cough, sore throat, fever
and others, they are advised to seek medical care as soon as possible.
Overdose Effects
The clinical signs of a possible overdose are not known. If overdose occurs, seek medical advice immediately.
Therapeutic Class
Vaso Protective
Storage Conditions
Store in a cool and dry place, away from light. Keep out of the reach of children.
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