Calcium Lactate Gluconate + Calcium Carbonate + Vitamin C
Indications
This is indicated in-
- Increased demand for Calcium and Vitamin-C, e.g. pregnancy, lactation, periods of rapid growth (childhood, adolescence), in old age
- During infectious disease and convalescence
- Treatment of calcium and vitamin-C deficiency
- Osteoporosis
- Premenstrual syndrome
- Postmenopausal problems
- Adjuvant in colds and influenza.
Pharmacology
Calcium is used as a pharmacological agent
in humans almost entirely to remedy deficiency. Adequate calcium in the
blood is so vital to a wide variety of bodily functions that our
internal biochemistry will not tolerate a deficiency even for short
periods.
Vitamin-C is an essential component of the diet as man can not synthesize vitamin-C. It is a very powerful reducing agent. Vitamin-C plays an important part in the response of the body to stress. It is important in the defense against infection.
Vitamin-C is an essential component of the diet as man can not synthesize vitamin-C. It is a very powerful reducing agent. Vitamin-C plays an important part in the response of the body to stress. It is important in the defense against infection.
Dosage & Administration
Adults and children above 7 years: 1 effervescent tablet daily
Children 3 to 7 years: ½ effervescent tablet daily
Infants: As prescribed by the physician
Dissolve one tablet in half glass (100 ml) of water.
Children 3 to 7 years: ½ effervescent tablet daily
Infants: As prescribed by the physician
Dissolve one tablet in half glass (100 ml) of water.
Interaction
Calcium Gluconate: Co-admin of high calcium
doses with thiazide diuretics may result in milk-alkali syndrome and
hypercalcaemia. May potentiate digoxin toxicity. Decreases effects of
calcium channel blockers. Enhanced absorption with calcitriol (a vitamin
D metabolite).
Calcium Carbonate: Co-administration with thiazide diuretics or vit D may lead to milk-alkali syndrome and hypercalcaemia. Decreased absorption with corticosteroids. Decreases absorption of tetracyclines, atenolol, iron, quinolones, alendronate, Na fluoride, Zn and calcium-channel blockers. Enhances cardiac effects of digitalis glycosides and may precipitate digitalis intoxication.
Vitamin C: Deferroxamine, hormonal contraceptives, flufenazine, warfarin, elemental iron, salicylates, warfarin, fluphenazine, disulfiram, mexiletine, vitamin B12.
Calcium Carbonate: Co-administration with thiazide diuretics or vit D may lead to milk-alkali syndrome and hypercalcaemia. Decreased absorption with corticosteroids. Decreases absorption of tetracyclines, atenolol, iron, quinolones, alendronate, Na fluoride, Zn and calcium-channel blockers. Enhances cardiac effects of digitalis glycosides and may precipitate digitalis intoxication.
Vitamin C: Deferroxamine, hormonal contraceptives, flufenazine, warfarin, elemental iron, salicylates, warfarin, fluphenazine, disulfiram, mexiletine, vitamin B12.
Contraindications
Hypercalcemia (e.g. in hyperparathyroidism,
vitamin-D overdosage, decalcifying tumors such as plasmocytoma, bone
metastases); severe hypercalciuria; severe renal failure.
Patients with hyperoxalauria, glucose-6- phosphate dehydrogenase deficiency, or iron overload. Larger doses may lead to gastrointestinal tract upset.
Patients with hyperoxalauria, glucose-6- phosphate dehydrogenase deficiency, or iron overload. Larger doses may lead to gastrointestinal tract upset.
Side Effects
In rare cases, mild gastrointestinal
disturbances (bloating, diarrhoea) can occur. In predisposed patients
prolonged treatment with high doses may promote the formation of calculi
in the urinary tract.
Pregnancy & Lactation
Calcium containing drugs have been widely
used in pregnancy by way of oral calcium supplementation or antacid
therapy. Calcium Carbonate can be safely used inlactating women.
Vitamin-C may be taken safely during pregnancy and lactation
Precautions & Warnings
For patients with mild hypercalciuria
(exceeding 300 mg = 7.5 mmol/24 hours), with mild or moderate impairment
of renal function or with a history of urinary concrements, monitoring
of calcium excretion in the urine is required. If necessary, the dosage
should be reduced or therapy should be discontinued. High doses of
vitamin-D and derivatives should be avoided during treatment with this
preparation unless especially indicated.
Since citrate salts have been reported to increase aluminium absorption, this medicine should be used with caution in patients with severely impaired renal function, especially those receiving aluminium-containing preparations. The sugar content should be taken into account by diabetic patients.
Since citrate salts have been reported to increase aluminium absorption, this medicine should be used with caution in patients with severely impaired renal function, especially those receiving aluminium-containing preparations. The sugar content should be taken into account by diabetic patients.
Overdose Effects
Acute overdosage has not been reported. It
would be expected to cause gastrointestinal disturbances but not to
result in hypercalcemia, except in patients treated with a very high
dosage of vitamin-D and derivatives.
Therapeutic Class
Specific mineral & vitamin combined preparations
Storage Conditions
Store at a cool and dry place and protected from light and moisture.
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