Chlorpheniramine Maleate
Indications
Chlorpheniramine Maleate is indicated in the following indications-
- Urticaria
- Sensitivity reactions
- Angioneurotic edema
- Vasomotor rhinitis
- Cough
- Common cold
- Motion sickness and
- Other allergic conditions.
Pharmacology
Chlorpheniramine Maleate is an alkylamine
antihistamine. It is one of the most potent histamine H1-receptor
blocking agents which is used as a potent antihistamine. This generally
causes less sedation than promethazine. Chlorpheniramine Maleate exerts
its effects by blocking H1-receptor competitively.
Dosage & Administration
Adult- Usual adult dose is 4 mg every 4-6 hours, maximum 24 mg daily.
Child-
Child-
- 6-12 years: 2 mg every 4-6 hours, maximum 12 mg daily.
- 2-5 years: 1 mg every 4-6 hours, maximum 6 mg daily.
- 1-2 years: 1 mg twice daily.
Interaction
Chlorphenamine maleate has been reported to
be incompatible with calcium chloride, kanamycin sulfate, noradrenaline
acid tartrate, pentobarbital sodium, and meglumine adipiodone.
Contraindications
Chlorpheniramine is contraindicated in patients hypersensitive to this agent, in newborn or premature infants.
Side Effects
Chlorpheniramine is well-tolerated, but
sometimes drowsiness, dizziness, muscular weakness, and gastrointestinal
upset may occur.
Pregnancy & Lactation
This drug should not be used in lactating mother and in pregnancy especially during the first trimester of pregnancy.
Precautions & Warnings
Chlorpheniramine should be used with
caution in patients with glaucoma and prostatic hypertrophy. During
therapy with chlorpheniramine, caution should be taken in driving
vehicles and operating machinery.
Overdose Effects
CNS depression (including sedation, apnea,
CV collapse), CNS stimulation (including insomnia, hallucination,
tremors, convulsions), tinnitus, blurred vision, dizziness, ataxia,
hypotension. Stimulation and atropine-like signs and symptoms (including
dry mouth, fixed dilated pupils, flushing, hyperthermia, Gl symptoms)
are more likely in children.
Therapeutic Class
Sedating Anti-histamine
Storage Conditions
Store in a cool (Below 25°C temperature) and dry place protected from light. Keep out of the reach of children.
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