Cilnidipine
Indications
Cilnidipine is indicated for the management
of hypertension for end-organ protection. It is reported to be useful
in elderly patients and in those with diabetes and albuminuria.
Cilnidipine has been increasingly used in patients with chronic kidney
disease
Hypertension is the term used to describe the presence of high blood pressure. The blood pressure is generated by the force of the blood pumped from the heart against the blood vessels. Thus hypertension is caused when there is too much pressure on the blood vessels and this effect can damage the blood vessel
Hypertension is the term used to describe the presence of high blood pressure. The blood pressure is generated by the force of the blood pumped from the heart against the blood vessels. Thus hypertension is caused when there is too much pressure on the blood vessels and this effect can damage the blood vessel
Pharmacology
Cilnidipine is a dihydropyridine
calcium-channel blocker. Cilnidipine binds to the dihydropy-ridine
binding sites of the L-type voltage dependent calcium channel and
inhibits Ca2+ influx across the cell membranes of vascular
smooth muscle cells via this channel, consequently vascular smooth
muscle is relaxed, causing vasodilation. Cilnidipine inhibits Ca2+ influx via N-type voltage dependent calcium channels in the sympathetic nerve cell membrane. The inhibition of Ca2+
influx via N-type voltage dependent calcium channel was observed over a
similar range of drug concentrations to those inhibiting L-type voltage
dependent Ca2+ channels. Consequently, release of
norepinephrine from sympathetic nerve terminals would be inhibited.
Cilnidipine is considered to suppress the reflex increase in heart rate
after blood pressure reduction.
Dosage & Administration
Adults: 5-10 mg once daily after breakfast. Maximum dose: 20 mg once daily.
Pediatric use: The safety of Cilnidipine in pediatric patients has not been established.
Elderly use: Since the elderly may be more susceptible to hypotension, therapy should be initiated with the lowest possible dose (5 mg).
Pediatric use: The safety of Cilnidipine in pediatric patients has not been established.
Elderly use: Since the elderly may be more susceptible to hypotension, therapy should be initiated with the lowest possible dose (5 mg).
Interaction
Other anti-hypertensive, antipsychotics
that cause hypotension, quinidine, carbamazepine, phenytoin, rifampicin,
cimetidine, erythromycin.
Contraindications
Cilnidipine is contraindicated in patients
with known sensitivity to Cilnidipine or any of the excipients or
patients having cardiogenic shock, recent MI or acute unstable angina
and severe aortic stenosis.
Side Effects
The most common side effects of Cilnidipine
are: Dizziness; flushing; headache; hypotension; peripheral oedema;
palpitations; GI disturbances; increased micturition frequency;
lethargy; eye pain; depression.
Pregnancy & Lactation
Cilnidipine should not be administered in
pregnant woman or woman having possibilities of being pregnant. It is
also advisable to avoid the administration of Cilnidipine to nursing
mothers. However, if the administration is indispensable, the patient
should be instructed to discontinue lactation.
Precautions & Warnings
Cilnidipine should be administered with
care in the following patients: patients with serious hepatic
dysfunction, patients with a history of serious adverse reactions to
calcium antagonists. During the discontinuation, the dosage should be
gradually decreased under close observation.
Therapeutic Class
Calcium-channel blockers
Storage Conditions
Store below 30°C, protected from light and moisture. Keep away from reach out of the children.
Showing 1 to 21 of 21 (1 Pages)