Cinnarizine + Dimenhydrinate
Indications
Cerebral circulatory disorders:
Disorders of balance:
- Prophylaxis and maintenance therapy for symptoms of cerebral vascular spasms and arteriosclerosis such as: dizziness, ear buzzing (tinnitus), vascular headache, unsociability and irritability, fatigue, sleep rhythm disorders such as premature awakening, involutional depressions, loss of memory and lack of concentration, incontinence and other disorders due to aging.
- Sequelae of cerebral and cranial trauma.
- Postapoplectic disorders.
- Migraine.
Disorders of balance:
- Prophylaxis and maintenance therapy for symptoms of labyrinthine arteriosclerosis; vestibular irritability; Meniere's syndrome such as vertigo, dizziness, giddiness, syncopal attacks, tinnitus, nystagmus, nausea and vomiting.
- Prophylaxis of motion sickness.
Pharmacology
This contains two active ingredients
Cinnarizine and Dimenhydrinate. The two substances belong to different
groups of medicines. Cinnarizine is part of a group called calcium
antagonists. Dimenhydrinate belongs to a group called antihistamines.
Both substances work by reducing symptoms of vertigo (a feeling of
dizziness or spinning) and nausea (feeling sick). The combination
product is more effective than the individual compounds.
Dosage & Administration
Adults: 1 tablet three times daily, to be taken after meals. Children and
adolescents under the age of 18 years: Not recommended
Elderly: Dosage as for adults.
adolescents under the age of 18 years: Not recommended
Elderly: Dosage as for adults.
Interaction
Concurrent use of alcohol, CNS depressants
or tricyclic antidepressants may potentiate the sedative effects of
either these drugs or of Cinnarizine and Dimenhydrinate. Therefore, it
is advisable to avoid these drugs while taking Cinnarizine and
Dimenhydrinate.
Contraindications
Cinnarizine and Dimenhydrinate should not
be used by patients with severe hepatic impairment. Cinnarizine and
Dimenhydrinate is contra-indicated in patients with known
hypersensitivity to the active substances or to any of the excipients.
Cinnarizine and Dimenhydrinate should not be used in patients with
angle-closure glaucoma, convulsions, suspicion of raised intracranial
pressure, and alcohol abuse or urine retention due to urethroprostatic
disorders.
Side Effects
Drowsiness, dry mouth, headache, and
stomach pain may occur. Rare side effects are impaired vision, allergic
reactions, light sensitivity, and difficulty in urinating. Other
possible reactions which may occur: weight gain, constipation, tightness
of the chest, jaundice, worsening of angle-closure glaucoma,
uncontrollable movements, unusual excitement and restlessness, severe
skin reactions.
Pregnancy & Lactation
Dimenhydrinate and cinnarizine should not be used during pregnancy and lactation.
Precautions & Warnings
Cinnarizine and Dimenhydrinate do not
reduce blood pressure significantly; however, it should be used with
caution in hypotensive patients. Cinnarizine and Dimenhydrinate should
be taken after meals to minimize any gastric irritation. Caution should
be exercised when administering Cinnarizine and Dimenhydrinate to
patients with Parkinson’s disease.
Overdose Effects
Drowsiness, dizziness and ataxia with
anticholinergic effects such as dry mouth, flushing of the face, dilated
pupils, tachycardia, pyrexia, headache and urinary retention. General
supportive measures should be used to treat respiratory insufficiency or
circulatory failure. Gastric lavage with isotonic sodium chloride
solution is recommended.
Therapeutic Class
Anti vertigo drugs
Storage Conditions
Store in a cool (below 30°C) and dry place. Keep away from light and out of reach of children.
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