Famotidine

Indications

Famotidine is indicated in-

Gastric ulcer
Duodenal ulcer
Anastomotic ulcer
Acute stress ulcer
Reflux esophagitis and
Zollinger-Ellison syndrome.

Famotidine is also indicated for the treatment of acute gastritis, chronic gastritis in the acute exacerbation stage.

Pharmacology

Famotidine is a histamine H2-receptor antagonist. Famotidine completely inhibits the action of histamine on H2- receptors of parietal cell. It inhibits basal, overnight and pentagastrin stimulated gastric acid secretion. The H2- receptor antagonist activity of Famotidine is slowly reversible, since the drug dissociates slowly from H2-receptor.

Dosage & Administration

Tablet:

For gastric ulcer, duodenal ulcer, anastomotic ulcer, upper gastro-intestinal hemorrhage, reflux esophagitis and Zollinger-Ellison syndrome: Usual dose for adults: Famotidine 20 mg twice daily (after breakfast and after supper or before bed time) or Famotidine 40 mg can be administered orally once daily at bed time.
For the treatment of acute gastritis, chronic gastritis in acute exacerbation stage: Usual dosage for adults is Famotidine 20 mg orally twice a day (after breakfast and after supper or before bed time). Also Famotidine 40 mg can be orally administered once a day (before bed time), dosage should be adjusted according to age and symptoms. Most ulcer patients heal within 4-8 weeks. For maintenance therapy the recommended oral dose is 20 mg once daily. Or, as directed by the registered physician.

Powder for Suspension:
Gastroesophageal Reflux Disease(GERD):

<1 year of age: 0.5 mg/kg/dose of famotidine oral suspension up to 8 weeks once daily in patients
Age 3 to 11 months: 0.5 mg/kg/dose twice daily up to 8 weeks
Age 1 to 2 months: 0.5 mg/kg/dose once daily up to 8 weeks
Neonates: 0.5 mg/kg/dose maximum once daily up to 8 weeks

Patients 1-16 years of age:

Gastroesophageal Reflux Disease(GERD): 1 mg/kg/day p.o. divided b.i.d. up to 40 mg b.i.d.
Duodonal ulcer: 0.5 mg/kg/day p.o. at bedtime or divided b.i.d. up to 40 mg/day.
Peptic ulcer: 0.5 mg/kg/day p.o. at bedtime or divided b.i.d. up to 40 mg/day.
Maintenance therapy: 40 mg at daily night.
Reflux esophagitis: 2 mg/kg/day
Zollinger-Ellison Syndrome: 40 mg 3 times daily.

Interaction

No data available.

Contraindications

Known hypersensitivity to any component of the drug.

Side Effects

Eruption, constipation, diarrhoea, dry mouth, nausea, vomiting, tachycardia, high blood pressure, headache, drowsiness or insomnia may rarely occur.

Pregnancy & Lactation

Pregnancy category B. There are no adequate and well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly needed. Caution should be exercised when Famotid is administered to a nursing woman.

Precautions & Warnings

The drug should be used in the minimum required amount depending upon the conditions of the diseases. The drug should be administered carefully with elderly patients, patients with renal failure and hepatic disorders.

Use in Special Populations

Use in Child: No data available.

Overdose Effects

No data available.

Therapeutic Class

H2 receptor antagonist

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

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Famotidine

Indications

Pharmacology

Dosage & Administration

Interaction

Contraindications

Side Effects

Pregnancy & Lactation

Precautions & Warnings

Use in Special Populations

Overdose Effects

Therapeutic Class

Storage Conditions

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