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Rosuvastatin

Indications

Rosuvastatin is indicated in-
  • Heterozygous Hypercholesterolemia (Familial and Non familial)
  • Homozygous Hypercholesterolemia (Familial)
  • Mixed Dyslipidemia (Fredrickson Type IIa and IIb)
  • Primary prevention of cardiovascular disease

Pharmacology

Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methyl glutaryl coenzyme A to mevalonate, a precursor of cholesterol. Rosuvastatin produces its lipid-modifying effects in two ways. First, it increases the number of hepatic LDL receptors on the cell surface to enhance uptake and catabolism of LDL. Second, Rosuvastatin inhibits hepatic synthesis of VLDL, which reduces the total number of VLDL and LDL particles.

Dosage

Dose range: 5-40 mg once daily. Use 40 mg dose only for patients not reaching LDL-C goal with 20 mg

HoFH: Starting dose 20 mg/day.

Pediatric patients with HeFH: 5-10 mg/day for patients 8 to less than 10 years age, and 5-20 mg/day for patients 10 to 17 years of age.

Pediatric patients with HoFH: 20 mg/day for patients 7 to 17 years of age.

Administration

Rosuvastatin can be taken with or without food, at any time of day.

Interaction

Remarkable drug interactions of Rosuvastatin are-
  • Cyclosporine: Combination increases Rosuvastatin exposure. Rosuvastatin dose should be limited to 5 mg once daily.
  • Gemfibrosil: Combination should be avoided. If used together, Rosuvastatin dose should be limited to 10 mg once daily.
  • Lopinavir/Ritonavir or atazanavir/ritonavir: Combination increases Rosuvastatin exposure. Rosuvastatin dose should be to 10 mg once daily.
  • Coumarin anticoagulants: Combination prolongs international normalized ratio (INR). Stable INR should be achieved prior to starting Rosuvastatin. INR should be monitored frequently until stable upon initiation or alteration of Rosuvastatin therapy.
  • Concomitant lipid-lowering therapies: Use with fibrates and niacin products may increase the risk of skeletal muscle effects.

Contraindications

Rosuvastatin is contraindicated if-
  • Known hypersensitivity to product components
  • Liver disease, which may include unexplained persistent elevations in hepatic transaminase levels
  • Pregnant women and women who may become pregnant
  • Nursing mothers

Side Effects

Rosuvastatin is generally well tolerated. The most frequent adverse events thought to be related to Rosuvastatin were headache, myalgia, constipation, asthenia, abdominal pain and nausea.

Pregnancy & Lactation

The safety in pregnant women has not been established. It is not known whether Rosuvastatin is excreted in human milk or not.

Precautions & Warnings

Skeletal muscle effects (e.g., myopathy and rhabdomyolysis): Risks increase with use of 40 mg dose, advanced age (>65 year), hypothyroidism, renal impairment and combination use with cyclosporine, lopinavir/ritonavir, atazanavir/ritonavir or certain other lipid-lowering drugs. Patients should be advised to promptly report unexplained muscle pain, tenderness or weakness. Rosuvastatin can be discontinued if signs or symptoms appear.

Liver enzyme abnormalities and monitoring: Persistent elevations in hepatic transaminases can occur.

Liver enzymes should be monitored before and during treatment

Use in Special Populations

Use in children: The safety and effectiveness in pediatric patients have not been established.

Therapeutic Class

Other Anti-anginal & Anti-ischaemic drugs, Statins

Storage Conditions

Keep below 30oC temperature, protected from light & moisture. Keep out of the reach of children.
Bestcol Tablet 10 mg

Bestcol Tablet 10 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

25.18Tk.

Bestcol Tablet 5 mg

Bestcol Tablet 5 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

8.00Tk.

Cholcut Tablet 10 mg

Cholcut Tablet 10 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

20.00Tk.

Cholcut Tablet 20 mg

Cholcut Tablet 20 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

30.00Tk.

Cholcut Tablet 5 mg

Cholcut Tablet 5 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

10.00Tk.

Creston Tablet  20 mg

Creston Tablet 20 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

25.00Tk.

Creston Tablet 10 mg

Creston Tablet 10 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

15.00Tk.

Creston Tablet 5 mg

Creston Tablet 5 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

10.00Tk.

Creva Tablet 10 mg

Creva Tablet 10 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

27.00Tk.

Creva Tablet 5 mg

Creva Tablet 5 mg

 Innovator's MonographIndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia..

14.00Tk.

Lipiros Tablet 10 mg

Lipiros Tablet 10 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

25.00Tk.

Lipiros Tablet 5 mg

Lipiros Tablet 5 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

12.50Tk.

Nestor Tablet 10 mg

Nestor Tablet 10 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

20.06Tk.

Nestor Tablet 5 mg

Nestor Tablet 5 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

10.03Tk.

Restat Tablet 10 mg

Restat Tablet 10 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

20.00Tk.

Restat Tablet 5 mg

Restat Tablet 5 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

10.00Tk.

Rocovas Tablet 20 mg

Rocovas Tablet 20 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

30.00Tk.

Rolip Tablet 10 mg

Rolip Tablet 10 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

20.00Tk.

Rolip Tablet 20 mg

Rolip Tablet 20 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

30.00Tk.

Rolip Tablet 5 mg

Rolip Tablet 5 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

10.00Tk.

Ropitor Tablet 10 mg

Ropitor Tablet 10 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

20.06Tk.

Ropitor Tablet 20 mg

Ropitor Tablet 20 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

30.10Tk.

Ropitor Tablet 5 mg

Ropitor Tablet 5 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

10.03Tk.

Rosetor Tablet 10 mg

Rosetor Tablet 10 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

20.00Tk.

Rosetor Tablet 20 mg

Rosetor Tablet 20 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

30.00Tk.

Rosetor Tablet 5 mg

Rosetor Tablet 5 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

10.03Tk.

Rostab Tablet 10mg

Rostab Tablet 10mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

20.07Tk.

Rostab Tablet 20mg

Rostab Tablet 20mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

25.08Tk.

Rostab Tablet 5mg

Rostab Tablet 5mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

10.03Tk.

Rostatin Tablet 10 mg

Rostatin Tablet 10 mg

IndicationsRosuvastatin is indicated in-Heterozygous Hypercholesterolemia (Familial and Non familial..

15.00Tk.

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