Benzoyl Peroxide
Indications
Topical therapy for the treatment of acne vulgaris.
Pharmacology
Benzoyl peroxide has mild keratolytic
effect and antimicrobial activity due to release of free-radical oxygen
which oxidizes bacterial protein. It is active against Staphylococcus
epidermidis and Propionibacterium acnes.
Dosage & Administration
Adult: As 2.5-10%
preparation: Apply 1-2 times daily after cleansing, may gradually
increase to tid if needed. Start with lower strength preparations. As
cleanser: Wash 1-2 times daily.
Child: ≥12 yr Same as adult dose.
Child: ≥12 yr Same as adult dose.
Interaction
There is no known interaction with other
medications which might be used cutaneously and concurrently with
Benzoyl Peroxide; however, drugs with desquamative, irritant and drying
effects should not be used concurrently with Benzoyl Peroxide gel.
Contraindications
Benzoyl Peroxide gel is contra-indicated in patients with known hypersensitivity to Benzoyl Peroxide.
Side Effects
The major adverse reaction reported to date
with Benzoyl Peroxide cutaneous therapy is irritation of the skin
including erythema, burning, peeling, dryness, itching, stinging,
feeling of skin tension locally at the site of application. This is
reversible when treatment is reduced in frequency or discontinued.
Allergic contact dermatitis, including face oedema, may occur.
Pregnancy & Lactation
Pregnancy Category C. Either
studies in animals have revealed adverse effects on the fetus
(teratogenic or embryocidal or other) and there are no controlled
studies in women or studies in women and animals are not available.
Drugs should be given only if the potential benefit justifies the
potential risk to the fetus.
Precautions & Warnings
Children, Pregnancy and lactation.
Overdose Effects
Benzoyl Peroxide gel is a preparation
indicated for topical treatment only. If the medication is applied
excessively, no more rapid or better results will be obtained and severe
irritation might develop. In this event, treatment must be discontinued
and appropriate symptomatic therapy should be instituted.
Therapeutic Class
Acne treatment preparations
Storage Conditions
Store in a cool and dry place, protected from light.
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