Ceflon Capsule 500 mg

Indications

Cefaclor is indicated in the treatment of the following infections: Otitis media, Lower respiratory tract infections, including pneumonia, bronchitis and acute exacerbation of chronic bronchitis, Upper respiratory tract infections, including pharyngitis and tonsillitis, Urinary tract infections, including pyelonephritis and cystitis, Skin and soft tissue infections, Sinusitis

Pharmacology

Cefaclor is a second generation cephalosporin antibiotic which has stability against b-lactamase inactivation and possesses a broad spectrum of activity. Cefaclor is active against the following organisms in vitro: Alpha and beta haemolytic Streptococci, Staphylococci; including coagulase-positive, coagulase negative and penicillinase-producing strains, Streptococcus pneumoniae, Streptococcus pyogenes (Group A b-haemolytic Streptococci), Branhamella catarrhalis, Escherichia coli, Proteus mirabilis, Klebsiella species Haemophilus influenzae, including ampicillin-resistant strains. Cefaclor is generally effective in the eradication of Streptococci from the nasopharynx.

Dosage

Adult-

Usual dose: 250 mg 8 hrly.

Bronchitis & pneumonia: 250 mg tid.

Sinusitis: 500 mg tid for 10 days.

Pneumonia & other more severe infections: Max: 4 gm/day for 28 days.

Acute gonococcal urethritis: 3 gm as a single dose combined with probenecid 1 gm.

Children- 

Recommended dose: 20 mg/kg/day in divided doses 8 hrly.

Bronchitis & pneumonia: 20 mg/kg/day in divided doses tid.

Serious infections, sinusitis, otitis media & infections: caused by less susceptible organisms 40 mg/kg/day in divided doses. Max: 1 gm/day.

Administration

May be taken with or without food.

Interaction

The nephrotoxicity of aminoglycoside antibiotics such as gentamicin and tobramicin may be enhanced by any cephalosporin. Therefore, one should be cautious in concomitant use of these categories of drugs.

Contraindications

Cefaclor is contraindicated in patients with known allergy to the Cephalosporin group of antibiotics.