Nepsy Tablet 300 mg
- Brand:Eskayef Pharmaceuticals Ltd
- Product Code: Gabapentin
- Availability: In Stock
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16.00Tk.
This product has a minimum quantity of 10
Indications
Gabapentin is indicated for-
- Neuropathic Pain.
- Adjunctive therapy in partial seizure and secondary generalized seizure.
Pharmacology
Gabapentin is an anti-convulsant. It is a structural analog of gamma-amino-butyric-acid (GABA). All pharmacological actions following administration of Gabapentin are due to the activity of parent compound. Gabapentin binds with the alpha-2-delta subunit of voltage gated L-type Calcium channel, and inhibits branched chain amino acid transferase & probably inhibits neurotransmitter release of excitatory amino acid.
Dosage
Neuropathic Pain: The treatment may be initiated as a single 300 mg dose on Day-1, than 300 mg twice on Day-2 and 300 mg thrice on Day-3. The dose can be subsequently be titrated up as needed for pain relief to a daily dose of 1800 mg (divided TID).
Epilepsy:
Epilepsy:
- Patients over 12 years of age: the effective dose of Gabapentin is 900 to 1800 mg/day given in three divided doses. The starting dose is 300 mg three times a day.
- Paediatric patients age 3-12 year: the starting dose should range from 10-15 mg/kg/day in 3 divided doses, and the effective dose reached by upward titration over a period of approximately three days.
Administration
Gabapentin can be taken orally with or without food.
Interaction
Antacids may reduce the bioavailability of Gabapentin by up to 20 %. Cimetidine may alter its reanal excretion. Gabapentin does not interact with other anti-epileptic drug or with oral contraceptive preparations.
Contraindications
Gabapentin is contraindicated in patients who have known hypersensitivity to the drug.
Side Effects
Fatigue, Dizziness, ataxia, weight gain, peripheral edema, dry mouth and somnolence may occur.
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