Description

Chlorhexidine is a very potent, cationic chemoprophylactic agent. It has a broad spectrum action, and is more effective against gm+ve than gm-ve bacteria. It acts by binding to negatively charged bacterial cell wall thereby disrupting membrane integrity and affecting its functions. In high concentrations, chlorhexidine is bactericidal.

Mechanism of Action

This preparation contains Chlorhexidine Gluconate and Isopropyl Alcohol Solution
Chlorhexidine Gluconate is an antiseptic effective against a wide range of bacteria, yeasts, some other fungi and viruses.
Chlorhexidine gluconate is most active at neutral or alkaline conditions. Its activity is reduced by the presence of blood or body fluids.
It binds strongly to skin, mucosa and other tissue and is therefore poorly absorbed.
It is bacteriostatic at low concentrations whilst at higher concentrations their activity is rapidly bactericidal.
They are both active against dermatophytic fungi (including the yeast C. Albicans) and enveloped viruses such as HIV.
Chlorhexidine binds with negatively charged bacterial cell wall that induces disrupting membrane integrity causes Cell wall destruction and cell death.

Isopropyl Alcohol binds with bacterial cell wall that Causes Cell wall protein coagulation and induces damage of bacterial cell wall and ultimate cell death.

Indication

HANDISOL is an antimicrobial preparation for:
• Pre-operative surgical hand disinfection.
• Antiseptic hand washing on the ward.
• Pre-operative and post operative skin antisepsis for patients undergoing elective surgery.
• Rapid Skin cleansing solution for hand disinfection prior to surgery & for routine use in the ward to reduce risk of cross-infection.

Contraindication

HANDISOL preparation is contraindicated for patients who have previously shown a hypersensitivity reaction to chlorhexidine. However, such rection are extremely rare.

Precaution

Avoid contact with brain, meninges, middle ear
Avoid contact with the eyes
This preparation is for external use only. Avoid use in body cavities.
This medicine contains flammable alcohol. Avoid naked flames and lighted objects, such as gas and electric fires and lit cigarettes and the use of artificial heat, e.g hairdryers.

Side Effects

Irritative skin reactions to chlorhexidine preparations can occasionally occur. Generalized allergic reactions to chlorhexidine have also been reported but are extremely rare.

Accidental Ingestion

Carry out a stomach lavage with milk, egg white, gelatin or mild soap water.

Storage

Store between 150c-250c. Keep out of reach of children.

Presentation

Packed in 250 ml HDPE container