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Niprolac 100 ml


  • Product Code: Lactulose 3.35/5mg/ml
  • Availability: In Stock

  • 114.34Tk.



Generic

Lactulose

 

Indications

Constipation (Chronic Constipation): In every case of chronic constipation, initial treatment should consist of a diet rich in fiber (vegetables, salads, fruits etc.) a generous amount of liquids and much physical exercise. Lactulose is only to be taken when these measures prove insufficient.

Intestinal flora disturbances:

  • In damaged to intestinal flora (e.g. following long-term antibiotic treatment)
  • gall bladder diseases
  • intestinal diseases ( Colitis, Diverticulosis, Megacolon)

Increased blood ammonia levels (hyper ammoniemia in hepatopathy, portal-systemic encephalopathy)

 

Pharmacology

Lactulose is a disaccharide that has been synthesized. Lactulose is digested in the colon by saccharolytic bacteria, which produces low molecular weight organic acids (mostly lactic acid), which lowers the pH of the colon contents, promotes water retention via an osmotic action, and therefore increases peristaltic activity. Because lactulose is only slightly absorbed, the pharmacokinetics of the absorbed substance have no bearing on the primary therapeutic effect.

 

Dosage & Administration

In constipation ( chronic constipation):

  • Adults: Initially 3-6 tea-spoons daily, In long-term therapy 1½-6 tea-spoons daily
  • Children up to 14 years: Initially 3 tea-spoons daily, In long-term therapy 1-2 tea-spoons daily
  • Infants and toddlers: Initially 1-2 tea-spoons daily, In long-term therapy 1 tea-spoon daily

In damaged intestinal flora:

  • Adults: 1-2 tea-spoons daily
  • Children: 1 tea-spoon daily

For reduction of blood ammonia level:

  • Hyper-ammoniemia in hepatopathy: a maximum of 18-30 tea-spoons daily.
  • In portal systemic encephalopathy: hourly doses of 6-9 tea-spoons of Lactulose solution may be used to induce the rapid laxation. When the laxative effect has been achieved, the dose may then be reduced.

 

Interaction

With lactulose, there are no major medication interactions. In misuse, potassium deprivation can amplify the glycosidic action of cardiac glycosides.

 

Contraindications

Galactose and/or lactose hypersensitivity; galactose-free diet; gastro-cardial symptom complex; possible intestinal obstruction

 

Side Effect

Flatulence, cramps, and stomach pain may occur at the start of therapy; this is quickly resolved by lowering the dosage. Overdosing might cause diarrhoea. Electrolyte loss is a common side effect of drug usage (primarily potassium).

 

Pregnancy & Lactation

Lactulose is classified as a pregnancy category B by the US Food and Drug Administration. Lactulose has been shown in studies to have no negative effects. A registered physician must make decisions about usage during pregnancy and breastfeeding.

 

Precautions & Warnings

Patients who are intolerant to lactulose should be given the sugar with caution. The dose used in the treatment of (pre) coma hepaticum is generally significantly greater, and diabetics should be aware of this.

 

Therapeutic Class

Osmotic purgatives

 

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

 

Pharmaceutical Name

NIPRO JMI Pharma Ltd.

Tags: Niprolac 100 ml