Metrocon 400 Tablet
- Product Code: Metronidazole 400mg
- Availability: In Stock
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1.90Tk.
Indications
Metronidazole is used to treat the following conditions:
- The prevention of anaerobic bacteria-related post-operative infections (particularly species of bacteroides and anaerobic streptococci).
- Anaerobe-caused septicaemia, bacteraemia, peritonitis, brain abscess, pelvic abscess, pelvic cellulitis, and post-operative wound infections.
- In the treatment of trichomoniasis of the urogenital tract.
- Bacterial vaginosis is a kind of bacterial vaginosis (also known as non-specific vaginitis).
- Amoebiasis in all its manifestations (intestinal, extra-intestinal disease and that of symptomless cyst passers).
- Giardiasis.
- Gingivitis with ulcers that is acute.
- Leg ulcers and pressure sores caused by anaerobic bacteria.
- Anaerobic microbes cause acute dental infections.
- Pseudomembranus colitis caused by antibiotics.
Pharmacology
Metronidazole belongs to the imidazole family of antibacterial drugs and is used as an antiprotozoal agent. Anaerobes decrease the 5-nitro group of Metronidazole metabolically. Metronidazole's bactericidal effect has been established in studies where the reduced form of the antibiotic interacts with DNA.
Dosage & Administration
Tablet and Suspension:
Trichomoniasis (Adults & Children over 10 yrs)-
- 200 mg tid or 400 mg bid for 7 days
- 800 mg in the morning and 1-2 gm at night for 2 days
- 2 gm as a single dose for 1 days
Trichomoniasis (Children)-
- Children 7-10 yrs: 100 mg tid
- Children 3-7 yrs: 100 mg bid
- Children 1-3 yrs: 50 mg tid
Intestinal amoebiasis (Adults & Children over 10 yrs)-
- 800 mg tid for 5 days
Intestinal amoebiasis (Children)-
- Children 7-10 yrs: 400 mg tid
- Children 3-7 yrs: 200 mg qid
- Children 1-3 yrs: 200 mg tid
Extra-intestinal & Asymptomatic amoebiasis (Adults & Children over 10 yrs)-
- 400-800 mg tid for 5-10 days
Extra-intestinal & Asymptomatic amoebiasis (Children)-
- Children 7-10 yrs: 200-400 mg tid
- Children 3-7 yrs: 100-200 mg qid
- Children 1-3 yrs: 100-200 mg tid
Giardiasis (Adults & Children over 10 yrs)-
- 2 gm once daily for 3 days
Giardiasis (Children)-
- Children 7-10 yrs: 1 gm once daily
- Children 3-7 yrs: 600-800 mg once daily
- Children 1-3 yrs: 500 mg once daily
Acute ulcerative gingivitis (Adults & Children over 10 yrs)-
- 200 mg tid for 3 days
Acute ulcerative gingivitis (Children)-
- Children 7-10 yrs: 100 mg tid
- Children 3-7 yrs: 100 mg bid
- Children 1-3 yrs: 50 mg tid
Acute dental infections (Adults & Children over 10 yrs)-
- 200 mg tid for 3-7 days
Bacterial Vaginosis (Adults & Children over 10 yrs)-
- 400 mg bid for 7 days
- 2 gm as a single dose for 1 days
Leg ulcers and pressure sores (Adults & Children over 10 yrs)-
- 400 mg tid for 7 days
Anaerobic infections (Adults & Children over 10 yrs)-
- 800 mg initially and then 400 mg tid for 7 days
Anaerobic infections (Children)-
- Children 1-10 yrs: 7.5 mg/kg tid
Surgical prophylaxis (Adults & Children over 10 yrs)-
- 400 mg tid started 24 hours before surgery for 1 days
Surgical prophylaxis (Children)-
- Children 1-10 yrs: 7.5 mg/kg tid
Vaginal Gel:
The recommended dose is one applicator full of Metronidazole gel (approximately 5 grams containing approximately 37.5 mg of Metronidazole) intravaginally once or twice a day for 5 days. For once a day dosing, Metronidazole gel should be administered at bedtime.
Suppository:
Anaerobic Infections-
- Adults: 1 g every 8 hours for 3 days, then 1 g every 12 hours.
- Children: 5-10 years: 500 mg every 8 hours for 3 days, then every 12 hours, Over 10 years adult dose.
Surgical Prophylaxis-
- Adults: 1 g 2 hours before surgery; up to 3 further doses of 1 g may be given every 8 hours for high risk procedures.
- Children: 5-10 years: 500 mg 2 hours before surgery; up to 3 further doses of 500 mg may be given every 8 hours for high risk procedures.
IV Infusion:
Metronidazole intravenous infusion requires no dilution and should not be mixed with any other drugs prior to administration.
- Adults and children over 12 years: Infuse 500 mg 8 hourly at a rate of 5 ml/minute and a maximum of 4 g should not be exceeded during a 24-hour period. Treatment for 7 days is sufficient for most patients, but treatment can be extended, especially for cases where reinfection is likely. For surgical prophylaxis, administration shortly before surgery should be followed by 8-hourly doses for the next 24 hours.
- Children under 12 years: 7.5 mg/kg body weight/day every 8 hours at a rate of 5 ml/minute.
Interaction
- Disulfiram: Psychotic responses have been observed in patients who were taking metronidazole and disulfiram at the same time.
- Alcohol: Alcoholic drinks and medicines containing alcohol should be avoided throughout therapy and for at least one day following due to the risk of a disulfiram-like (antabuse effect) response (flushing, vomiting, tachycardia). Oral anticoagulant treatment (warfarin): Reduced hepatic catabolism causes potentiation of the anticoagulant action and increased hemorrhagic risk. In the case of co-administration, prothrombin time should be checked more often and anticoagulant medication should be modified throughout metronidazole treatment.
- Metronidazole has the potential to raise lithium levels in the blood.
- Cyclosporin: When co-administration is required, serum cyclosporin and serum creatinine should be regularly monitored.
- Metronidazole elimination is enhanced with phenytoin or phenobarbital, resulting in lower plasma levels.
- 5-Fluorouracil: Reduced clearance of 5-fluorouracil, resulting in higher 5-fluorouracil toxicity.
- Metronidazole can raise plasma levels of busulfan, which can lead to severe busulfan poisoning.
Contraindications
Metronidazole is not recommended for people who have previously had hypersensitivity to Metronidazole or other Nitroimidazole derivatives.
Side Effects
During therapy, metallic taste, nausea, vomiting, diarrhoea, sleepiness, and rashes may occur.
Pregnancy & Lactation
Metronidazole's Pregnancy Category in the United States is B. However, no appropriate and well-controlled trials in pregnant women exist. Because animal reproduction studies aren't usually predictive of human response, this medication should only be taken during pregnancy if absolutely necessary. Metronidazole has been proven to pass through human milk. As a result, while administering Metronidazole to a nursing mother, extreme caution should be taken.
Precautions & Warnings
- If metronidazole must be taken for a longer period of time than normal, it is advised that hematological tests, particularly leucocyte count, be performed on a regular basis and that patients be watched for adverse responses such as peripheral or central neuropathy (such as paresthesia, ataxia, dizziness, convulsive seizures).
- Metronidazole should be used with care in individuals suffering from hepatic encephalopathy.
- Patients should be informed that metronidazole may cause their urine to discolor.
Therapeutic Class
Storage Conditions
Store at temperatures below 30°C. Keep away from direct sunlight. Keep medications out of children's reach. Do not use after the expiry date.
Pharmaceutical Name
Tags: Metrocon 400 Tablet