Generic
Paracetamol
Indications
Fever, common cold, and influenza, headache, toothache, earache, bodyache, myalgia, neuralgia, dysmenorrhoea, sprains, colic pain, back pain, post-operative pain, postpartum discomfort, inflammatory pain, and post vaccination pain in children are among the conditions for which paracetamol is prescribed. It's also used to treat rheumatic and osteoarthritic pain, as well as joint stiffness.
Pharmacology
Paracetamol is an analgesic and antipyretic with just a minor anti-inflammatory effect. Paracetamol (Acetaminophen) is hypothesized to work largely in the central nervous system (CNS), improving pain threshold by blocking both isoforms of the cyclooxygenase enzymes COX-1, COX-2, and COX-3, which are involved in prostaglandin (PG) formation. Paracetamol is a para aminophenol derivative that has analgesic, antipyretic, and anti-inflammatory effects. One of the most extensively used, safest, and fastest acting analgesics is paracetamol. It is well tolerated and free of aspirin's different adverse effects.
Dosage and Administration
Tablet:
Adult: 1-2 tablets every 4 to 6 hours up to a maximum of 4 gm (8 tablets) daily.
Children (6-12 years): ½ to 1 tablet 3 to 4 times daily. For long term treatment it is wise not to exceed the dose beyond 2.6 gm/day.
Extended Release Tablet:
Adults & Children over 12 years: Two tablets, swallowed whole, every 6 to 8 hours (maximum of 6 tablets in any 24 hours).The tablet must not be crushed.
Syrup/Suspension:
Children under 3 months: 10 mg/kg body weight (reduce to 5 mg/kg if jaundiced) 3 to 4 times daily.
3 months to below 1 year: ½ to 1 teaspoonful 3 to 4 times daily.
1-5 years: 1 -2 teaspoonful 3 to 4 times daily.
6-12 years: 2-A teaspoonful 3 to 4 times daily.
Adults: 4-8 teaspoonful 3 to 4 times daily.
Suppository:
Children 3-12 months: 60-120 mg,4 times daily.
Children 1-5 years: 125-250 mg 4 times daily.
Children 6-12 years: 250-500 mg 4 times daily.
Adults & children over 12 years: 0.5-1 gm 4 times daily.
Paediatric Drop:
Children Upto 3 months: 0.5 ml (40 mg)
4 to 11 months: 1.0 ml (80 mg)
7 to 2 years: 1.5 ml (120 mg). Do not exceed more than 5 dose daily for a maximum of 5 days.
Paracetamol tablet with actizorb technology: It dissolves up to five times faster than standard Paracetamol tablets. It is a fast acting and safe analgesic with marked antipyretic property. It is specially suitable for patients who, for any reason, can not tolerate aspirin or other analgesics.
Adults and children (aged 12 years and over): Take 1 to 2 Tablets every four to six hours as needed. Do not take more than 8 caplets in 24 hours.
Children (7 to 11 years): Take ½-1 Tablet every four to six hours as needed. Do not take more than 4 caplets in 24 hours. Not recommended in children under 7 years.
Interaction
Fever, common cold, and influenza, headache, toothache, earache, bodyache, myalgia, neuralgia, dysmenorrhoea, sprains, colic pain, back pain, post-operative pain, postpartum discomfort, inflammatory pain, and post vaccination pain in children are among the conditions for which paracetamol is prescribed. It's also used to treat rheumatic and osteoarthritic pain, as well as joint stiffness.
Contraindications
It is not recommended if you have a known hypersensitivity to paracetamol.
Side Effects
Although haematological responses such as thrombocytopenia, leucopenia, pancytopenia, neutropenia, and agranulocytosis have been observed, paracetamol's side effects are usually minor. Pancreatitis, rashes, and other allergic responses can happen at any time.
Pregnancy & Lactation
According to the USFDA, pregnancy category B. This medication should only be used during pregnancy if absolutely necessary.
Precautions & Warnings
Patients with compromised kidney or liver function should use paracetamol with caution. Patients taking other medicines that damage the liver should use caution when using paracetamol.
Therapeutic Class
Non opioid analgesics
Storage Conditions
Keep away from light and heat in a dry location. Keep out of children's reach.
Pharmaceutical Name
Aristopharma Ltd.
Tags: Xpa 60 ml