Tamen 60 ml

Generic

Paracetamol

Indications

Fever, common cold, and influenza, headache, toothache, earache, bodyache, myalgia, neuralgia, dysmenorrhoea, sprains, colic pain, back pain, post-operative pain, postpartum discomfort, inflammatory pain, and post vaccination pain in children are among the conditions for which paracetamol is prescribed. It's also used to treat rheumatic and osteoarthritic pain, as well as joint stiffness.

Pharmacology

Paracetamol is an analgesic and antipyretic with just a minor anti-inflammatory effect. Paracetamol (Acetaminophen) is hypothesized to work largely in the central nervous system (CNS), improving pain threshold by blocking both isoforms of the cyclooxygenase enzymes COX-1, COX-2, and COX-3, which are involved in prostaglandin (PG) formation. Paracetamol is a para aminophenol derivative that has analgesic, antipyretic, and anti-inflammatory effects. One of the most extensively used, safest, and fastest acting analgesics is paracetamol. It is well tolerated and free of aspirin's different adverse effects.

Dosage & Administration

Tablet:

• Adult: 1-2 tablets every 4 to 6 hours up to a maximum of 4 gm (8 tablets) daily.
• Children (6-12 years): ½ to 1 tablet 3 to 4 times daily. For long term treatment it is wise not to exceed the dose beyond 2.6 gm/day.

Extended-Release Tablet:

• Adults & Children over 12 years: Two tablets, swallowed whole, every 6 to 8 hours (maximum of 6 tablets in any 24 hours).The tablet must not be crushed.

Syrup/Suspension:

• Children under 3 months: 10 mg/kg body weight (reduce to 5 mg/kg if jaundiced) 3 to 4 times daily.
• 3 months to below 1 year: ½ to 1 teaspoonful 3 to 4 times daily.
• 1-5 years: 1 -2 teaspoonful 3 to 4 times daily.
• 6-12 years: 2-A teaspoonful 3 to 4 times daily.
• Adults: 4-8 teaspoonful 3 to 4 times daily.

Suppository:

• Children 3-12 months: 60-120 mg,4 times daily.
• Children 1-5 years: 125-250 mg 4 times daily.
• Children 6-12 years: 250-500 mg 4 times daily.
• Adults & children over 12 years: 0.5-1 gm 4 times daily.

Paediatric Drop:

• Children Upto 3 months: 0.5 ml (40 mg)
• 4 to 11 months: 1.0 ml (80 mg)
• 7 to 2 years: 1.5 ml (120 mg). Do not exceed more than 5 dose daily for a maximum of 5 days.

Paracetamol tablet with actizorb technology: It dissolves up to five times faster than standard Paracetamol tablets. It is a fast acting and safe analgesic with marked antipyretic property. It is specially suitable for patients who, for any reason, can not tolerate aspirin or other analgesics.

• Adults and children (aged 12 years and over): Take 1 to 2 Tablets every four to six hours as needed. Do not take more than 8 caplets in 24 hours.
• Children (7 to 11 years): Take ½-1 Tablet every four to six hours as needed. Do not take more than 4 caplets in 24 hours. Not recommended in children under 7 years.

Interaction

Patients who have taken barbiturates, tricyclic antidepressants and alcohol may show diminished ability to metabolize large doses of Paracetamol. Alcohol can increase the hepatotoxicity of Paracetamol overdosage. Chronic ingestion of anticonvulsants or oral steroid contraceptives induce liver enzymes and may prevent attainment of therapeutic Paracetamol levels by increasing first-pass metabolism or clearance.

Contraindications

It is not recommended if you have a known hypersensitivity to paracetamol.

Side Effects

A Although hematological responses such as thrombocytopenia, leucopenia, pancytopenia, neutropenia, and agranulocytosis have been observed, paracetamol's side effects are usually minor. Pancreatitis, rashes, and other allergic responses can happen at any time.

Pregnancy & Lactation

According to the USFDA, pregnancy category B. This medication should only be used during pregnancy if absolutely necessary.

Precautions & Warnings

Paracetamol should be given with caution to patients with impaired kidney or liver function. Paracetamol should be given with care to patients taking other drugs that affect the liver.

Therapeutic Class

Non opioid analgesics

Storage Conditions

Protect from light and moisture by storing in a cool, dry place below 30°C. Keep out of children's reach.

Pharmaceutical Name

Eskayef Pharmaceuticals Ltd.