Tamenol 325 Tablet

Generic

Paracetamol + Tramadol Hydrochloride

Indications

• The management of moderate to moderately severe pain in adults is the indication for this pill.
• The treatment of acute pain in the short term (five days or less).

Pharmacology

Paracetamol is an analgesic and antipyretic with just a minor anti-inflammatory effect. Paracetamol (Acetaminophen) is hypothesized to work largely in the central nervous system (CNS), improving pain threshold by blocking both isoforms of the cyclooxygenase enzymes COX-1, COX-2, and COX-3, which are involved in prostaglandin (PG) formation. Paracetamol is a para aminophenol derivative that has analgesic, antipyretic, and anti-inflammatory effects. One of the most extensively used, safest, and fastest acting analgesics is paracetamol. It is well tolerated and free of aspirin's different adverse effects.

Tramadol could be a centrally acting manufactured opioid analgesic. In spite of the fact that its mode of activity isn't totally caught on, from creature tests, at slightest two complementary instruments show up appropriate: official of parent and M1 metabolite to μ-opioid receptors and powerless restraint of the reuptake of norepinephrine and serotonin. Opioid movement is due to both moo liking authoritative of the parent compound and higher liking authoritative of the O-demethylated metabolite M1 to μ-opioid receptors. Tramadol has been appeared to repress reuptake of norepinephrine and serotonin in vitro, as have a few other opioid analgesics.These components may contribute freely to the by and large pain relieving profile of tramadol.

Dosage & Administration

• For the management of moderate to moderately severe pain: The recommended dose is 1 or 2 tablets every 4 to 6 hours as needed for pain relief up to a maximum of 8 tablets per day.
• In case of short-term (five days or less) management of acute pain: The recommended dose is 2 tablets every 4 to 6 hours as needed for pain relief up to a maximum of 8 tablets per day.
• This tablet can be administered without regard to food.

Contraindications

Patients who have previously shown hypersensitivity to tramadol, paracetamol, any other component of this medication, or opioids should not be given Tramadol & Paracetamol combo pills. In any case where opioids are contraindicated, this is not a good idea.

Side Effects

Asthenia, fatigue, hot flushes, dizziness, headache, tremor, abdominal pain, constipation, diarrhea, dyspepsia, dry mouth, nausea, vomiting, anorexia, anxiety, confusion, euphoria, insomnia, nervousness, somnolence pruritus, rash, increased sweating, etc. are all possible side effects of this therapy.

Pregnancy & Lactation

Pregnancy Classification C. In pregnant women, there are no sufficient and well-controlled trials. Only if the possible benefit outweighs the risk to the fetus should this combo preparation be used during pregnancy. Because the safety of this combination preparation in babies and newborns has not been tested, it is not advised for obstetrical preoperative medication or post-delivery analgesia in nursing mothers.

Precautions & Warnings

• This combination of preparations may impair mental or physical abilities needed for potentially dangerous occupations like driving a car or operating machinery.
• Alcohol-containing beverages should not be consumed with this combination preparation.
• This combination preparation should not be taken in conjunction with any other tramadol or paracetamol-containing products, including over-the-counter medications.
• When using tranquilizers, hypnotics, or other opiate-containing analgesics, this combination preparation should be used with caution.

Therapeutic Class

Non-steroidal Anti-inflammatory Drugs (NSAIDs).

Storage Conditions

Store in a cool, dry location. Do not allow yourself to become frozen. All drugs should be kept out of the reach of youngsters.

Pharmaceutical Name

Eskayef Pharmaceuticals Ltd.