Pyrex T Tablet

Generic

Paracetamol + Tramadol Hydrochloride

Indications

This tablet is indicated in

• The management of moderate to severe pain in adults.
• Short-term management of acute pain (five days or less).

Pharmacology

Paracetamol has analgesic and antipyretic properties with low anti-inflammatory activity. Paracetamol (acetaminophen) is believed to have a major effect on the CNS, increasing the pain threshold by inhibiting the two isoforms of the cyclooxygenase enzymes, COX1, COX2 and COX3 involved in the synthesis of prostaglandins (PG). Paracetamol is a para-aminophenol derivative, with analgesic and antipyretic properties with low anti-inflammatory activity. Paracetamol is one of the most widely used, safest, and fastest pain relievers. It is well tolerated and free from the various side effects of aspirin.

Tramadol is a centrally acting synthetic opioid analgesic. Although its mode of action is not fully understood, based on animal studies, at least two additional mechanisms may be applicable: maternal binding and metabolite of M1 to receptors in opioid bodies and weak reuptake inhibitors. noradrenaline and serotonin. Opioid activity is due to both the low affinity parent compound and the higher affinity binding of the odemethylated M1 metabolite to opioid receptors. Tramadol has been shown to inhibit the reuptake of norepinephrine and serotonin in vitro, as have several other opioid pain relievers.

Dosage & Administration

For the management of moderate to moderately severe pain: The recommended dose is 1 or 2 tablets every 4 to 6 hours as needed for pain relief up to a maximum of 8 tablets per day.

For short-term acute pain control (five days or less): The recommended dose is 2 tablets every 4-6 hours as needed for pain relief up to a maximum of 8 tablets per day.

This tablet can be used regardless of food.

Contraindications

Combination tramadol and paracetamol tablets should not be given to patients with a previous hypersensitivity to tramadol, paracetamol, any of the other ingredients of this product, or to opioids. This is contraindicated in all cases of opioid contraindications.

Side Effect

The following side effects may occur with this treatment: asthenia, fatigue, hot flushes, dizziness, headache, tremor, abdominal pain, constipation, diarrhea, indigestion, dry mouth, sadness vomiting, vomiting, loss of appetite, anxiety, confusion, euphoria, insomnia, nervousness, drowsiness, itching, rash, increased sweating, etc.

Pregnancy & Lactation

Pregnancy group C. There are no adequate and well-controlled studies in pregnant women. This combination should only be used during pregnancy if there is potential benefit to the fetus. This combined preparation is not recommended for preoperative obstetric surgery or for postoperative analgesia in nursing mothers as its safety in neonates and neonates has not been studied.

Precautions & Warnings

This combined preparation may affect the mental or physical capacities necessary to perform potentially hazardous work such as driving a car or operating machinery.

This combined preparation should not be taken with alcoholic beverages.

Patients should be advised not to take this combined preparation in combination with other products containing tramadol or paracetamol, including overdose preparations.

This combined preparation should be used with caution when taking medications such as sedatives, hypnotics or other opiates containing pain relievers.

Therapeutic Class

Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

Store in a cool and dry place. Do not freeze. Keep all medicines out of the reach of children.

Pharmaceutical Name

Concord Pharmaceuticals Ltd.