A-One Plus Tablet 500mg + 65mg

Generic

Paracetamol + Caffeine

Indications

This is stated in the following circumstance:

• Headache
• Migraine
• Toothache
• Neuralgia
• Feverishness
• Pain during your period
• Throat irritation
• Backache
• Assist in lowering the temperature
• Cold and flu aches and pains

Pharmacology

This is a paracetamol and caffeine combo. Paracetamol is an analgesic and antipyretic with just a minor anti-inflammatory effect. Caffeine is a theophylline-like xanthine derivative that is an alkaloid. Caffeine improves the solubility and transmembrane permeability of paracetamol by forming an intermolecular connection with it. Caffeine also raises the pain threshold and enhances pain tolerance. Caffeine has the ability to increase vascular tone in the brain, which is another benefit in the treatment of migraines and headaches.

Dosage & Administration

Adult dose: 1-2 tablets every 4-6 hours. Maximum dose: 8 tablets daily.

Child dose: Not recommended for children below 12 years.

Interaction

Anticonvulsants may lower serum levels (e.g. phenytoin, barbiturates, carbamazepine). With prolonged use, warfarin and other coumarins may have a stronger anticoagulant impact. Metoclopramide and domperidone help to speed up absorption. Probenecid has the potential to raise serum levels. Chloramphenicol levels in the blood may rise. Colestyramine may inhibit absorption within 1 hour after administration. Phenothiazine can cause severe hypothermia.

Contraindications

In patients with significant renal function impairment and hepatic disorders, paracetamol is contraindicated (Viral Hepatitis). Hypersensitivity to paracetamol or caffeine is well-known.

Side Effects

Although haematological responses such as thrombocytopenia, leukopenia, pancytopenia, neutropenia, and agranulocytosis have been described, paracetamol's side effects are usually minor. Pancreatitis, rashes, and other allergic responses can happen at any time.

Pregnancy & Lactation

Before consuming paracetamol or caffeine, pregnant women should inform their doctors. While breast-feeding, you can take paracetamol and caffeine.

Precautions & Warnings

Caffeine and paracetamol should be used with caution in the following situations: Patients with hepatic or renal failure, as well as those who are taking additional hepatotoxic drugs. It is best to avoid using the medicine for an extended period of time without consulting a doctor.

Therapeutic Class

Non opioid analgesics

Storage Conditions

Protect from light and moisture by storing in a cool, dry location. All drugs should be kept out of the reach of youngsters.

Pharmaceutical Name

Apex Pharmaceuticals Ltd.