Servipep 20 Tablet

Generic

Famotidine

Indications

• Famotidine is used to treat gastric ulcers.
• Ulcer in the duodenum
• Ulcer anastomotic
• Acute stress ulcer is a type of ulcer that appears suddenly.
• Zollinger-Ellison syndrome with reflux esophagitis
• Famotidine is also used to treat acute gastritis and chronic gastritis that has reached an acute exacerbation stage.

Pharmacology

Famotidine works by blocking histamine H2-receptors. Famotidine totally blocks histamine's activity on parietal cell H2-receptors. It suppresses stomach acid production in the baseline, overnight, and pentagastrin-stimulated states. Famotidine's H2- receptor antagonist effect is reversible since the drug dissociates slowly from the H2-receptor.

Dosage & Administration

Tablet:

• For gastric ulcer, duodenal ulcer, anastomotic ulcer, upper gastro-intestinal hemorrhage, reflux esophagitis and Zollinger-Ellison syndrome: Usual dose for adults: Famotidine 20 mg twice daily (after breakfast and after supper or before bed time) or Famotidine 40 mg can be administered orally once daily at bed time.
• For the treatment of acute gastritis, chronic gastritis in acute exacerbation stage: Usual dosage for adults is Famotidine 20 mg orally twice a day (after breakfast and after supper or before bed time). Also Famotidine 40 mg can be orally administered once a day (before bed time), dosage should be adjusted according to age and symptoms. Most ulcer patients heal within 4-8 weeks. For maintenance therapy the recommended oral dose is 20 mg once daily. Or, as directed by the registered physician.

Powder for Suspension:

Gastroesophageal Reflux Disease(GERD):

• <1 year of age: 0.5 mg/kg/dose of famotidine oral suspension up to 8 weeks once daily in patients
• Age 3 to 11 months: 0.5 mg/kg/dose twice daily up to 8 weeks
• Age 1 to 2 months: 0.5 mg/kg/dose once daily up to 8 weeks
• Neonates: 0.5 mg/kg/dose maximum once daily up to 8 weeks

Patients 1-16 years of age:

• Gastroesophageal Reflux Disease(GERD): 1 mg/kg/day p.o. divided b.i.d. up to 40 mg b.i.d.
• Duodonal ulcer: 0.5 mg/kg/day p.o. at bedtime or divided b.i.d. up to 40 mg/day.
• Peptic ulcer: 0.5 mg/kg/day p.o. at bedtime or divided b.i.d. up to 40 mg/day.
• Maintenance therapy: 40 mg at daily night.
• Reflux esophagitis: 2 mg/kg/day
• Zollinger-Ellison Syndrome: 40 mg 3 times daily.

Contraindications

Known hypersensitivity to any component of the drug.

Side Effects

Eruption, constipation, diarrhoea, dry mouth, nausea, vomiting, tachycardia, high blood pressure, headache, drowsiness or insomnia may rarely occur.

Pregnancy & Lactation

Category B pregnancy. In pregnant women, there are no sufficient and well-controlled trials. This medication should only be used during pregnancy if absolutely necessary. When Famotid is given to a nursing woman, it should be done with caution.

Precautions & Warnings

Depending on the severity of the ailment, the medicine should be used in the smallest dose possible. Patients who are elderly, have renal failure, or have hepatic diseases should be given the medicine with caution.

Therapeutic Class

H2 receptor antagonist

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Pharmaceutical Name

SANDOZ (A Novartis Division)