Fluvin OD 150 Tablet

Generic

Fluconazole

Indications

Fluconazole is used to treat vaginal candidiasis, oropharyngeal and esophageal candidiasis, and cryptococcal meningitis. It is also useful in the treatment of candida infections of the urinary tract, peritonitis, and systemic candida infections (including candidemia, disseminated candidiasis and pneumonia).

Pharmacology

Fluconazole is an antifungal triazole. It is a strong inhibitor of fungus cytochrome P-450 enzymes. The cytochrome P-450 enzyme system is a necessary component of fungal cell membranes and is responsible for ergosterol production.

Dosage & Administration

Adult (oral)-

• Vaginal candidiasis: 150 mg as a single dose.
• Oropharyngeal candidiasis: 200 mg on the first day, followed by 100 mg once daily. Clinical evidence of this infection generally resolves within several days, but treatment should be continued for at least 2 weeks to decrease the likelihood of relapse.
• Esophageal candidiasis: 200 mg on the first day, followed by 100 mg once daily. Doses up to 400 mg/day may be used. Patients should be treated for a minimum of three weeks and for at least two weeks following resolution of symptoms.
• Systemic candida infections: Optimal therapeutic dosage and duration of therapy have not been established. Sometimes, doses of up to 400 mg daily have been used.
• Urinary tract infections caused by candida and peritonitis: 50-200 mg daily have been used.
• Cryptococcal meningitis: 400 mg on the first day, followed by 200 mg once daily.
• Prophylaxis in patients undergoing bone marrow transplantation: 400 mg once daily.

Child (oral):

• Doses of 3-6 mg/kg daily have been used. Doses up to 12 mg/kg is recommended.

Intravenous-

• Adult: Invasive candidal infections including candidaemia and disseminated candidiasis and cryptococcal infections including meningitis, by IV, 400 mg initially then 200 mg daily, increased if necessary to 400 mg daily, treatment continued according to response (at least 6-8 weeks for cryptococcal meningitis)
• Child: 6-12 mg/kg daily (every 72 hours in neonate up to 2 weeks old, every 48 hours in neonate 2-4 weeks old); maximum 400 mg daily. Prevention of relapse of cryptococcal meningitis, by IV, 100-200 mg daily.

Interaction

Concurrent use of cyclosporin or phenytoin with Fluconazole raises cyclosporin or phenytoin plasma levels. Fluconazole and warfarin usage together increases prothrombin time. When fluconazole is combined with rifampicin, the level of rifampicin decreases.

Contraindications

Fluconazole should not be used in individuals who have previously demonstrated hypersensitivity to Fluconazole or similar triazole drugs.

Side Effects

Fluconazole is a medication that is well tolerated. The most frequent Fluconazole side effects are nausea, vomiting, stomach discomfort, diarrhoea, headache, and skin rash.

Pregnancy & Lactation

Fluconazole's pregnancy category in the United States is C. Fluconazole should thus be avoided during pregnancy and breastfeeding unless the potential advantages to the other outweigh the potential dangers to the baby.

Precautions & Warnings

Fluconazole should be used with care in individuals suffering from proarrhythmic disorders.

Therapeutic Class

Subcutaneous and mycosis medications

Storage Conditions

Keep away from light and heat in a dry area. Keep out of children's reach.

Pharmaceutical Name

Glaxo Smithkline Bangladesh Limited