Miki-H 10 Cream

Indications

For the topical treatment of inflammatory dermatoses in which infection by susceptible organisms and inflammatory conditions coexist, for example intertrigo and infectious eczema. For wet or dry eczema or dermatitis, including atopic eczema, primary or contact atopic eczema, or seborrheic eczema, including acne-related diseases. Also for eczema include visceral inflammation, perianal and genital dermatitis. Organisms sensitive to miconazole are dermatophytes and pathogenic yeasts (eg Candida spp.): There are also many Gram-positive bacteria including many strains of Streptococcus and Staphylococcus.

Pharmacology

Miconazole is a substituted imidazole, belonging to the family of azoles useful in the treatment of superficial candidiasis and skin infections, tinea versicolor and tinea versicolor, acanthameaba, seborrheic dermatitis. Also active against Aspergillus spp., Cryptococcus neoformans, Pseudalescheria boydii and some gram-positive bacteria including Staphylococci and Streptococci.

Hydrocortisone is a natural glucocorticoid, currently prepared synthetically. Its important function is in skin lesions such as inflammation. It also has antipruritic, antispasmodic and vasoconstrictor activity.

Miconazole is an imidazole antifungal agent which interferes with the synthesis of ergosterol and thus modifies the permeability of cell membranes of susceptible fungi. Thus causing the destruction of the fungus, when applied to the skin, hydrocortisone will be absorbed into the skin cells. It blocks the release of certain chemicals, which are responsible for inflammation. Thus, hydrocortisone reduces inflammation.

Dosage & Administration

Apply to the affected area as a thin film two or four times daily for 1 to 2 weeks. Rub it well with your finger until this cream fully vanished on the skin. Treatment should be continued at least one week after the disappearance of all signs and symptoms. The same dosage applies to both adults and children.

Interaction

Amphotericin antagonizes the action of miconazole.

Contraindications

It is contraindicated in people who are hypersensitive to it or to any of its ingredients. Should not be used by pregnant and lactating women without consulting a doctor.

Side Effects

Rarely, local sensitization can occur. Long-term use may decrease the natural production of hormones by the adrenal glands.

Pregnancy & Lactation

Administration of corticosteroids to pregnant animals in high doses may cause abnormalities in fetal development. Topical steroids should not be widely used during pregnancy.

Precautions & Warnings

To be dispensed only on prescription from an approved doctor. Keep out of the reach of CHILDREN. Take note or consult a doctor in case of prolonged use by children and the elderly.

Therapeutic Class

Hydrocortisone & Combined preparations

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Pharmaceutical Name

Orion Pharma Ltd.