Citivas
- Brand:Square Pharmaceuticals Ltd.
- Product Code: Citivas 500 mg
- Availability: In Stock
-
50.00Tk.
Indications
Citicoline Sodium is
indicated in-
- Cerebrovascular disease e.g.
ischemia due to stroke, where Citicoline accelerates the recovery of
consciousness & overcoming motor deficit. Treatment within the first
24 hours after onset in patients with moderate to severe stroke increases
the probability of complete recovery in 3 months.
- Cerebral insufficiency (e.g.
dizziness, memory loss, poor concentration & disorientation) due to
head trauma or brain injury.
- Cognitive dysfunction due to
degenerative disease (Alzheimer's disease)
- Parkinson's disease: Citicoline
has been shown to be effective as co-therapy for Parkinson's disease.
Pharmacology
Citicoline is a
naturally occurring substance that is an essential intermediate in the
synthesis of structural phospholipids of cell membrane. Oral dose of Citicoline
is metabolized to choline & cytidine. These then enter into the systemic
circulation, cross the blood-brain barrier and recombine to form Citicoline
within the central nervous system. Citicoline activates the biosynthesis of
structural phospholipids in the neuronal membrane, promotes rapid repair of
injured cell surface & mitochondrial membrane & increases the level of
various neurotransmitters like acetylcholine & dopamine. Citicoline has
neuroprotective effects in situations of hypoxia & ischemia, as well as
improved learning & memory performance in animal models for the aging
brain. Citicoline inhibits the activation of Phospholipase A2 to prevent
apoptotic & necrotic cell death.
Dosage & Administration
Oral:
- Immediate treatment of stroke
due to a clot (ischemic stroke): 500-2000 mg of Citicoline per day, start
within 24 hours of stroke.
- For decline in thinking skills
due to stroke: 1000-2000 mg of Citicoline per day.
- Chronic cerebrovascular
disease: 1000 mg daily in divided dose with or between meals for ongoing
disease of the blood vessels that serve the brain.
Injection:
- 1 to 2 injections daily.
- Adjust dosage according to the
severity.
- Can be administered through
intramuscular (IM), or intravenous (IV) [ 3 to 5 minutes] route.
* চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Interaction
Citicoline may enhance
the effects of levodopa, carbidopa & entacapone. Citicoline must not be
administered with products containing meclophenoxate.
Contraindications
Patients with
hypertonic of the parasympathetic nervous system.
Side Effects
Occasionally
Citicoline may exert stimulating action of the parasympathetic system as well
as a fleeting & discrete hypotensive effect.
Pregnancy & Lactation
There are no adequate
& well controlled studies of Citicoline during pregnancy & lactation.
Citicoline should be used during pregnancy & lactation only if the
potential benefits justify the potential risks.
Precautions & Warnings
In case of persistent
intracranial hemorrhage, it is recommended not to exceed the dose of 1000 mg of
Citicoline daily.
Use in Special Populations
Geriatric use: No
dosage adjustment is required & the usual dose can be administered.
Therapeutic Class
CNS stimulant drugs
Storage Conditions
Keep below 30°C
temperature, away from light & moisture. Keep out of the reach of children.
Tags: Citivas