Deprex
- Brand:Square Pharmaceuticals Ltd.
- Product Code: Deprex 10 mg
- Availability: In Stock
-
5.00Tk.
Indications
Olanzapine is
indicated for the acute and maintenance treatment of schizophrenia and related
psychoses where positive symptoms (e.g. delusions, hallucinations, disordered
thinking, hostility and suspiciousness) and/or negative symptoms (e.g.
flattened affect, emotional and social withdrawal, poverty of speech) are
prominent. Olanzapine is indicated for the treatment of acute manic or mixed
episodes in bipolar disorder, with or without psychotic features and with or
without a rapid cycling course
Pharmacology
Olanzapine is an
antipsychotic agent and has affinities for serotonin 5HT2A/2C, 5HT3, 5HT6;
dopamine D1, D2, D3, D4, D5; cholinergic muscarinic receptors M1-M5; α1
adrenergic; and histamine H1 receptors. The mechanism of action of Olanzapine,
as with other drugs having efficacy in schizophrenia, is unknown. However, it has
been proposed that this drug’s efficacy in schizophrenia is mediated through a
combination of dopamine and serotonin type 2 (5HT2) antagonism. Olanzapine is
well absorbed after oral administration, reaching peak plasma concentrations
within 5 to 8 hours. The absorption is not affected by food. Olanzapine is not
mutagenic or clastogenic as well as not carcinogenic.
Dosage
Schizophrenia,
combination therapy for Mania, Bipolar Disorder: The initial dose is 5-10 mg once daily.
Daily dosage may subsequently be adjusted on the basis of individual clinical
status within the range of 5-20 mg daily. Dosage greater than 10 mg daily only
after reassessment. Maximum dose is 20 mg daily.
Monotherapy for Mania: Initially 15 mg once daily. Daily dosage may
subsequently be adjusted on the basis of individual clinical status within the
range of 5-20 mg daily. Dosage greater than 15 mg only after reassessment.
Maximum dose is 20 mg daily.
* চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Administration
Olanzapine can be
given without regard to meals. Gradual tapering of the dose should be
considered while discontinuing Olanzapine.
* চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Interaction
Olanzapine may
antagonize the effects of levodopa and dopamine agonists. Drugs that induce
CYP1A2 or glucoronyl transferase enzymes e.g, Omeprazole and Rifampicin, may
increase Olanzapine clearance. Inhibitors of CYP1A2 may potentially inhibit
Olanzapine elimination. Carbamazepine may increase the clearance of Olanzapine.
Concomitant administration of activated charcoal reduces the oral
bioavailability of Olanzapine by 50-60%. Caution should be taken when
Olanzapine is administered with centrally acting drugs and alcohol.
Contraindications
Olanzapine is
contraindicated in those patients with a known hypersensitivity to any
ingredient of the product as well as in patients with known risk for
narrow-angle glaucoma.
Side Effects
Very common
undesirable effects are somnolence and weight gain. Besides increased appetite,
elevated glucose levels, elevated triglyceride levels, dizziness, akathisia,
Parkinson's disease, dyskinesia, orthostatic hypotension, mild and transient
anticholinergic effects including constipation and dry mouth, asthenia, edema
and photosensitivity reaction etc. may be observed.
Pregnancy & Lactation
Olanzapine should be
used in pregnancy only if the potential benefits justify the potential risk to
the foetus. So, patients should be advised to notify their physician if they
become pregnant or intend to become pregnant during treatment with Olanzapine.
There is no report to show teratogenecity. Patients should not breast feed if
they are taking Olanzapine.
Precautions & Warnings
Olanzapine should be
used cautiously in patients who have a history of seizures or have conditions
associated with seizures. Olanzapine should be used cautiously in patients
with low leukocyte and/or neutrophil counts for any reason, drug induced bone
marrow depression/toxicity caused by radiation therapy or chemotherapy,
hypereosinophilic conditions, impaired hepatic function, and patients using
hepatotoxic medicines, centrally acting drug and medicines know to increase QT
interval, especially in the elderly. Patients should be cautioned about
operating hazardous machinery, including motor vehicles.
Use in Special Populations
Children: Olanzapine has not been studied in subjects
under 18 years of age.
Elderly patients (age
65 and over): starting dose 5
mg/day
Patients with hepatic,
renal impairment: starting dose 5
mg/day
Therapeutic Class
Atypical neuroleptic
drugs
Storage Conditions
Keep below 30°C
temperature, away from light & moisture. Keep out of the reach of children.
Tags: Deprex