Dermasol
- Brand:Square Pharmaceuticals Ltd.
- Product Code: Dermasol 0.05%
- Availability: In Stock
-
76.00Tk.
Indications
Clobetasol Propionate
is indicated for adults, elderly and children over 1 year in following
dermatoses.
- Psoriasis (excluding widespread
plaque psoriasis)
- Recalcitrant dermatoses
- Lichen planus
- Discoid lupus erythematosus
- Other skin conditions which do
not respond satisfactorily to less potent steroids
Pharmacology
Clobetasol Propionate
is a very potent topical corticosteroid. It has anti-inflammatory, antipruritic
and vasoconstrictive properties. It shows anti-inflammatory activity via
multiple mechanisms to inhibit late phase allergic reactions. It decreases the density
of mast cells, chemotaxis and activation of eosinophils. It also reduces
cytokine production and inhibits the metabolism of arachidonic acid.
Dosage
Adults, elderly and
children over 1 year: Apply a thin layer
of Clobetasol Propionate Cream or Ointment to the affected skin areas twice
daily and rub in gently and completely. Repeated short courses of Clobetasol
Propionate may be used to control exacerbations. In more resistant lesions,
especially where there is hyperkeratosis, the effect of Clobetasol can be
enhanced, if necessary, by occluding the treatment area with polythene film.
Overnight occlusion only is usually adequate to bring about a satisfactory
response. Clobetasol Propionate is super-high potency topical corticosteroids;
therefore, treatment should be limited to 2 consecutive weeks. The maximum
weekly dose should not be exceeded 50 gm/week. In case of children, courses
should be limited if possible to five days and reviewed weekly.
* চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Administration
Route of
administration: Cutaneous. Creams are especially appropriate for moist or
weeping surfaces. Ointments are especially appropriate for dry, lichenified or
scaly lesions.
* চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Interaction
Co-administered drugs
that can inhibit CYP3A4 (eg ritonavir, itraconazole) have been shown to inhibit
the metabolism of corticosteroids leading to increased systemic exposure.
Contraindications
It is contraindicated
in patient with hypersensitivity to any component of the preparation. It should
not be used in rosacea, acne vulgaris, perioral dermatitis, perianal and
genital pruritus, pruritus without inflammation, untreated cutaneous
infections.
Side Effects
The most reported side
effects are burning and stinging sensation. Less frequent adverse reactions are
itching, skin atrophy, cracking and fissuring of the skin. Cushing syndrome has
been reported in infants and adults as a result of prolonged use of topical
Clobetasol Propionate formulations.
Pregnancy & Lactation
There are limited data
from the use of Clobetasol Propionate cream in pregnant women. Topical
administration of corticosteroids to pregnant animals can cause abnormalities
of foetal development. The relevance of this finding to humans has not been
established. However, the administration of Clobetasol Propionate Cream during
pregnancy and lactation should only be considered if the expected benefit to
the mother outweighs the possible risks of treatment.
It is unknown whether this drug is excreted in human milk. Because many drugs
are excreted in human milk, caution should be exercised when Clobetasol
Propionate Cream is administered to a nursing woman.
Precautions & Warnings
In case of using
occlusive dressings, the skin should be cleansed before a fresh dressing is
applied. Topical corticosteroids should be used with caution in psoriasis as
rebound relapses, and development of local or systemic toxicity due to impaired
barrier function of the skin may occur. If used on the face, treatment should
be limited to 5 days. When Clobetasol Propionate used on eyelids, care should
be taken to avoid the eyes as cataract and glaucoma might result from repeated
exposure.
Use in Special Populations
In infants and
children under 12 years of age, long-term continuous topical corticosteroid
therapy should be avoided where possible, as adrenal suppression can occur.
Children are more susceptible to the use of topical corticosteroids which develops
atrophic changes.
Overdose Effects
Acute overdosage is
very unlikely to occur, however, in the case of chronic over-dosage or misuse
the features of hypercortisolism may occur and in this situation topical
steroid should be discontinued.
Therapeutic Class
Other Topical
corticosteroids
Storage Conditions
Keep below 30°C
temperature, protected from light and moisture. Do not freeze. Keep out of the
reach of children.
Tags: Dermasol