Dermasol-N
- Brand:Square Pharmaceuticals Ltd.
- Product Code: Dermasol-N (0.5 mg+5 mg+1 Lac IU)/gm
- Availability: In Stock
-
76.00Tk.
Indications
This preparation is
indicated in-
- Short courses treatment of
recalcitrant eczemas.
- Neurodermatoses.
- Psoriasis (excluding widespread
plaque psoriasis) where secondary bacterial infection or fungal infection
is present, suspected or likely to occur.
- Other inflammatory conditions
which do not respond satisfactorily to less active steroids.
Pharmacology
Clobetasol Propionate
is a very potent corticosteroid. It is prescribed to treat severe inflammatory
skin disorders such as eczema and psoriasis that have not responded to weaker
corticosteroids. Neomycin Sulphate is an antibiotic of the aminoglycoside type
and is used to treat infections with bacteria. Nystatin is an antifungal that
kills fungi and yeasts by interfering with their cell membranes. The mechanism
of the topical steroids like Clobetasol, in general, is unclear. However,
Clobetasol Propionate is highly active corticosteroid with topical
anti-inflammatory activity. The major effect of Clobetasol Propionate on skin
is a nonspecific anti-inflammatory response, partially due to vasoconstriction
and decrease in collagen synthesis. Neomycin binds to the ribosomal 30s and 50s
sub-units of susceptible bacteria and inhibits protein synthesis. Neomycin also
causes a misreading of the genetic codes of the mRNA template and this causes
incorrect amino acids to be incorporated into the growing polypeptide chain.
Nystatin acts by binding to sterols in the cell membrane of the fungus with a
resultant change in membrane permeability allowing leakage of intracellular
components.
Dosage & Administration
Adults: Apply sparingly to the affected area once or
twice daily until improvement occurs. In very resistant lesion, especially
where there is hyperkeratosis, the anti-inflammatory effect of this preparation
can be enhanced (if necessary) by occluding the treatment area with polythene.
Treatment should not be continued for more than 7 days without medical
supervision. If a longer course is necessary, it is recommended that treatment
should not be continued for more than 4 weeks without the patient's condition
being reviewed.
Elderly: This preparation is suitable for use in
elderly. Caution should be exercised in cases where a decrease in renal
function exists and significant systemic absorption of Neomycin Sulphate may
occur.
Children: This preparation is suitable for use in
children (2 years and over) at the same dose as adults. A possibility of
increased absorption exists in very young children, thus this cream/ointment is
not recommended for use in neonates and infants (younger than 2 years).
* চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Interaction
Neomycin Sulphate can
intensify and prolong the respiratory depressant effects of neuromuscular
blocking agents following significant systemic absorption. However, if used in
accordance with the recommendations, systemic exposure to Neomycin Sulphate is
expected to be minimal and drug interactions are unlikely to be significant. No
hazardous interactions have been reported with use of Clobetasol Propionate or
Nystatin.
Contraindications
This medication is
contraindicated in rosacea, acne vulgaris and perioral dermatitis, primary
cutaneous viral infection (eg-Herpes simplex, chicken pox) and hypersensitivity
to the preparation.
Side Effects
As with other topical
corticosteroids, prolonged use of large amount or treatment of extensive areas
can result in sufficient systemic absorption to produce the features of
hypercortisolism. The effect is more likely to occur in infants and children
and if occlusive dressings are used. Prolonged and intensive treatment with
highly active corticosteroid preparations may cause local atrophic changes in
the skin such as thinning, striae, and dilatation of the superficial blood
vessels, particularly when occlusive dressings are used, or when skin folds are
involved. There are reports of pigmentation changes and hypertrichosis with
topical steroids.
Pregnancy & Lactation
There is little
information to demonstrate the possible effect of topically applied Neomycin in
pregnancy and lactation. However, Neomycin present in the maternal blood can
cross the placenta and may give rise to a theoretical risk of foetal toxicity,
thus the use of the preparation is not recommended in pregnancy and lactation.
The safety of Clobetasol Propionate has not been established in lactating
mothers.
Precautions & Warnings
Long-term continuous
topical therapy should be avoided where possible, particularly in infants and
children, as adrenal suppression can occur readily even without occlusion. If
applied to the eyelids, care is needed to ensure that the preparation does not
enter the eye, as glaucoma might result. If this medication does enter the eye,
the affected eye should be thoroughly washed with copious amount of water.
Overdose Effects
Acute overdosage is
very unlikely to occur. No overdose-related problem yet reported. However, in
the case of chronic overdosage or misuse, the features of hypercortisolism may
appear and in this situation, topical steroids should be discontinued
gradually.
Therapeutic Class
Clobetasol /
Clobetasone & Combined Preparations
Storage Conditions
Store below 25°C
temperature. Do not freeze. Keep out of reach of children.
Tags: Dermasol-N