Dermasol-S
- Brand:Square Pharmaceuticals Ltd.
- Product Code: Dermasol-S 0.05%
- Availability: In Stock
-
201.00Tk.
Indications
Clobetasol Propionate
scalp solution is indicated in the topical therapy of recalcitrant
corticosteroid-responsive dermatoses of the scalp, including recalcitrant cases
of psoriasis and seborrheic dermatitis.
Pharmacology
Clobetasol Propionate
is a very potent topical corticosteroid. It has anti-inflammatory, antipruritic
and vasoconstrictive properties. It shows anti-inflammatory activity via
multiple mechanisms to inhibit late phase allergic reactions. It decreases the
density of mast cells, chemotaxis and activation of eosinophils. It also
reduces cytokine production and inhibits the metabolism of arachidonic acid.
Dosage & Administration
Clobetasol Propionate
spray: Apply required quantity
of spray of once or twice daily to the affected areas of the scalp and gently
rub in. The total dose applied should not exceed 50 ml weekly. If necessary,
Clobetasol Propionate scalp solution may be massaged into the scalp using the
tips of the fingers. Therapy should be discontinued if no response is noted
after one week or as soon as the lesion heals. It is advisable to use
Clobetasol Propionate scalp solution for brief periods only.
Clobetasol Propionate
shampoo: It should be applied
to the dry (not wet) scalp once a day to the affected areas only. It should be
massaged gently into the lesions and left in place for 15 minutes before
lathering and rinsing. Treatment should be limited to 4 consecutive weeks.
Total dosage of shampoo should not exceed 50 g per week. Under 18 years this
preparation is not recommended.
Scalp Solution: Apply required quantity of spray of
Clobetasol Scalp Solution once or twice daily to the affected areas of the
scalp and gently rub in. The total dose applied should not exceed 50 ml weekly.
If necessary, Clobetasol Scalp Solution may be massaged into the scalp using
the tips of the fingers. Therapy should be discontinued if no response is noted
after one week or as soon as the lesion heals. It is advisable to use Clobetasol
Scalp Solution for brief periods only.
* চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Contraindications
- Infections of the scalp
- Hypersensitivity to the
preparation
- Use is not indicated in
dermatoses in children under one year of age
Side Effects
As with other
corticosteroids, prolonged use of large amounts or treatment of extensive
areas, can result in sufficient systemic absorption to produce the features of
hypercortisolism. This effect is more likely to occur in infants and children,
and if occlusive dressings are used. Local atrophy may occur after prolonged
treatment. In rare instances, treatment of psoriasis with corticosteroids (or
its withdrawal) is thought to have provoked the pustular form of the disease.
If signs of hypersensitivity appear with the use of Clobetasol Propionate Scalp
Solution then application should be stopped immediately.
Pregnancy & Lactation
Topical administration
of corticosteroids to pregnant animals can cause abnormalities of foetal
development. The relevance of this finding to human beings has not been
established; however, topical steroids should not used extensively in
pregnancy, i.e. in large amounts for prolonged periods. The safe use of
Clobetasol Propionate during lactation has not been established.
Precautions & Warnings
Care must be taken to
keep the preparation away from the eyes. Long-term continuous therapy with
Clobetasol Propionate scalp solution should be avoided where possible,
particularly in infants and children, as adrenal suppression can occur even
without occlusion. Topical corticosteroids may be hazardous in psoriasis for a
number of reasons including rebound relapses, development of tolerance, risk of
generalized pustular psoriasis and development of local or systemic toxicity
due to impaired barrier function of the skin. If used on psoriasis, careful
patient supervision is important. Appropriate antimicrobial therapy should be
used whenever treating inflammatory lesions which have become infected. Any
spread of infection requires withdrawal of topical corticosteroid therapy and
systemic administration of antimicrobial agents. Bacterial infection is
encouraged by the warm, moist conditions induced by occlusive dressings, and so
the skin should be cleansed before a fresh dressing is applied.
Therapeutic Class
Other Topical
corticosteroids
Storage Conditions
Keep below 30°C
temperature, protected from light and moisture. Do not freeze. Keep out of the
reach of children.
Tags: Dermasol-S