Dormitol
- Brand:Square Pharmaceuticals Ltd.
- Product Code: Dormitol 7.5 mg
- Availability: In Stock
-
10.00Tk.
Indications
Midazolam is indicated
in-
- Short-term treatment of
insomnia.
- Sedation in premedication
before surgical or diagnostic procedures.
Description
Midazolam is a
sleep-inducing agent characterized by a rapid onset and short duration of
action. It also exerts an anxiolytic, anticonvulsant and muscle-relaxant
effect.
Pharmacology
The actions of
benzodiazepines such as midazolam are mediated through the inhibitory
neurotransmitter gamma-aminobutyric acid (GABA), which is one of the major
inhibitory neurotransmitters in the central nervous system. Benzodiazepines
increase the activity of GABA, thereby producing a sedating effect, relaxing
skeletal muscles, and inducing sleep, anesthesia, and amnesia. Benzodiazepines
bind to the benzodiazepine site on GABA-A receptors, which potentiates the
effects of GABA by increasing the frequency of chloride channel opening. These
receptors have been identified in different body tissues including the heart
and skeletal muscle, although mainly appear to be present in the central
nervous system.
Dosage & Administration
Oral dosage:
- For adults: 7.5-15 mg daily.
- In elderly and
debilitated patients: The
recommended dose is 7.5 mg.
- In premedication: 15 mg of Midazolam should be given 30-60 minutes
before the procedure.
Intravenous
administration:
- Endoscopic or
Cardiovascular Procedures:
In healthy adults, the initial dose is approximately 2.5 mg. In cases of
severe illness and in elderly patients, the initial dose must be reduced
to 1 to 1.5 mg.
- Induction of
Anesthesia: The dose is 10-15 mg.
Intramuscular
administration:
- Adult: 0.07-0.1 mg/kg body weight. The usual dose is about 5
mg.
- Children: 0.15-0.20 mg/kg
- Elderly and
debilitated patients: 0.025-0.05
mg/kg
Rectal administration
in children:
- For preoperative
sedation: Rectal administration of the
ampoule solution (0.35-0.45 mg/kg) 20-30 min. before induction of general
anesthesia.
* চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Interaction
Midazolam can enhance
the central sedative effect of neuroleptics, tranquillizers, antidepressants,
sleep-inducing drugs, analgesics, anaesthetics, antipsychotics, anxiolytics,
antiepileptic drugs and sedative antihistamines.
Contraindications
Midazolam must not be
given to patients with severe respiratory insufficiency, severe hepatic
insufficiency, myasthenia gravis, sleep apnea syndrome and with known
hypersensitivity to benzodiazepines or to any component of the product
Side Effects
At the start of
therapy, drowsiness during daytime, confusion, fatigue, headache and muscle
weakness may occur which usually disappear with repeated administration.
Following parenteral (IV or IM) administration of Midazolam, fluctuations in
vital signs have been noted including respiratory depression, apnea, variations
in blood pressure and pulse rate.
Pregnancy & Lactation
Midazolam should be
avoided during pregnancy unless there is no safer alternative. Since Midazolam
passes into breast milk, it should not be administered to breast-feeding
mothers.
Precautions & Warnings
Midazolam IV should be
administered very slowly.
Overdose Effects
Extreme overdosage may
lead to coma, areflexia, cardiorespiratory depression and apnea. The effects of
overdosage can be controlled with benzodiazepine antagonist flumazenil.
Therapeutic Class
Benzodiazepine
hypnotics, Benzodiazepine sedatives
Storage Conditions
Protect from light and
moisture, store in cool and dry place. Keep out of the reach of children.
Tags: Dormitol