Doxacil
- Brand:Square Pharmaceuticals Ltd.
- Product Code: Doxacil 100 mg
- Availability: In Stock
-
2.00Tk.
Indications
Doxycycline Hydrochloride
is indicated in the following infections caused by susceptible microorganisms:
- Respiratory tract
infections: Pneumonia, influenza,
sinusitis, bronchitis, tonsillitis, tracheitis.
- Gastrointestinal
tract infections: Cholera, traveler's diarrhea,
shigella dysentery, acute intestinal amebiasis.
- Chlamydial
infections: Lympho-granuloma venereum,
psittacosis, trachoma.
- Sexually
transmitted diseases: Non
gonococcal urethritis, acute pelvic inflammatory disease, uncomplicated
urethral and endocervical or rectal infections, gonorrhoea, syphilis,
pyelonephritis, cystitis.
- Other infections: Impetigo, furunculosis, inclusion conjunctivitis,
brucellosis, tularemia, cellulitis, acne and Q-fever.
Description
Doxycycline is a
highly active broad-spectrum antibiotic of tetracycline group. It is effective
against a wide range of Gram-positive and Gram-negative bacteria, spirochete,
mycoplasma, rickettsia and mycobacteria. Doxycycline is used as an alternate to
penicillin in the treatment of gonorrhoea and syphilis. Doxycycline has its
main mechanism of action on protein synthesis. Inside the bacterial cell, it
inhibits protein synthesis.
Pharmacology
Doxycycline
Hydrochloride is a semisynthetic tetracycline antibiotic with broad spectrum
activity. It is primarily a bacteriostatic antibiotic. It has a similar
spectrum of activity to other tetracyclines but in particular is more active
against Staphylococcus aureus and Nocardia. The drug is often active against
penicillin-resistant strains of Staphylococcus aureus and against strains of
those organisms that are resistant to other Tetracyclines. Certain
Gram-negative strains of E. coli, Proteus mirabilis and Klebsiella, which are
often resistant to Tetracycline, may be sensitive to Doxycycline. In addition,
70-90% of the various anaerobes are sensitive to Doxycycline and Bacteroides
fragilis is more likely to be sensitive to Doxycycline than to other tetracyclines.
Doxycycline is active against most strains of Haemophilus influenzaeand is
particularly useful for infections with H. ducreyi, Actinomyces, Brucella and
Vibrio cholerae. It is also active against Nocardia, Chlamydia, Mycoplasma and
a wide range of Rickettsiae. Doxycycline is active against spirochetes such as
Borellia recurrentis, Treponema pallidum and Treponema pertenue. It is also
active against Plasmodium falciparum.
Dosage
Usual dose: 200 mg on first day, then 100 mg daily for
7-10 days.
Severe infections
(including refractory urinary tract infections): 200 mg daily for 10 days.
Acne: 100 mg daily.
Uncomplicated genital
chlamydia, non-gonococcal urethritis: 100 mg twice daily for 7-21 days (14-21 days in pelvic
inflammatory disease).
* চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Administration
Capsules should be
swallowed whole with plenty of fluid during meals while sitting or standing.
* চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Interaction
Absorption of
tetracyclines is impaired by antacid containing aluminium, calcium or
magnesium, and iron containing preparation. Absorption of tetracyclines is also
impaired by bismuth salicylate. Barbiturates, carbamazepine and phenytoin
decrease half-life of doxycycline. Concurrent use of tetracyclines may render
oral contraceptive less effective. Patients who are on anticoagulant therapy
may require downward adjustment of their anticoagulant dosages. It is advisable
to avoid giving tetracyclines in conjunction with penicillin.
Contraindications
Doxycycline is
contraindicated to the patients who have shown hypersensitivity to any of the
tetracyclines. Doxycycline is contraindicated to the children under 8 years of
age. It is also contraindicated to pregnant women and to the lactating mothers.
Side Effects
Nausea, vomiting,
diarrhoea, skin rashes, hemolytic anaemia, eosinophilia may be reported.
Pregnancy & Lactation
Doxycycline should be
avoided in pregnant women, because of the risk of both staining and effect on
bone growth in the foetus. Doxycyclines enter breast milk, and mothers taking
these drugs should not breastfeed their child.
Precautions & Warnings
The use of drugs of
the tetracycline class during tooth development (last half of pregnancy,
infancy and childhood to the age of 8 years) may cause permanent discoloration
of teeth. Tetracyclines drugs, therefore should not be used in this age group.
Therapeutic Class
Tetracycline group of
drugs
Storage Conditions
Keep all medicines out
of reach of children. Store in a cool and dry place, protected from light.
Tags: Doxacil