Dyvon
- Brand:Square Pharmaceuticals Ltd.
- Product Code: Dyvon 0.005% w/w
- Availability: In Stock
-
352.00Tk.
Indications
Calcipotriol cream
& ointment is indicated for the topical treatment of chronic stable plaque
type psoriasis vulgaris in adult patients.
Pharmacology
Calcipotriol is a
non-steroidal antipsoriatic agent, derived from vitamin D. Calcipotriol
exhibits a vitamin D-like effect by competing for the 1,25(OH)2D3 receptor.
Calcipotriol is as potent as 1,25(OH)2D3, the naturally occurring active form
of vitamin D, in regulating cell proliferation and cell differentiation, but
much less active than 1,25(OH)2D3 in its effect on calcium metabolism.
Calcipotriol induces differentiation and suppresses proliferation (without any
evidence of a cytotoxic effect) of keratinocytes, thus reversing the abnormal
keratinocyte changes in psoriasis. The therapeutic goal envisaged with
calcipotriol is thus a normalization of epidermal growth.
Dosage & Administration
Calcipotriol cream
& ointment should be applied topically to the affected area twice daily
(i.e. in the morning and in the evening). Less frequent application may be
indicated after the initial period of treatment. After satisfactory improvement
has occurred, treatment should be discontinued. If recurrence takes place after
discontinuation, the treatment may be reinstituted. Experience is lacking in
the use of calcipotriol for periods longer than 1 year. The maximum recommended
weekly dose of calcipotriol cream is 100 gm/week.
* চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Contraindications
Calcipotriol cream
& ointment is contraindicated in those patients with a history of
hypersensitivity to any of the components of the preparations. It is also
contraindicated in patients with known disorders of calcium metabolism.
Side Effects
Photosensitivity
reactions, skin discolouration, bullous eruption, skin exfoliation, contact
dermatitis and allergic reactions have been reported with topical calcipotriol
therapy.
Pregnancy & Lactation
Safety for use in
pregnancy has not been established. Therefore calcipotriol should not be used
during pregnancy unless benefits clearly outweigh the risks. It is not known
whether calcipotriol is excreted in breast milk, therefore, the drug should be
used during lactation only if the benefits clearly outweigh the risks.
Calcipotriol should not be applied to the chest area during breast feeding to
avoid possible ingestion by infants.
Precautions & Warnings
Calcipotriol cream
& ointment is not recommended for use in patients with generalized pustular
psoriasis, guttate psoriasis and erythrodermic exfoliate psoriasis.
Calcipotriol cream & ointment is not recommended for use on the face.
Use in Special Populations
Calcipotriol cream
& ointment should not be used in children, as there is inadequate
experience with its use.
Therapeutic Class
Topical Vitamin D
& related preparations
Storage Conditions
Store below 25° C,
away from light and moisture. Do not freeze. Keep all medicines out of reach of
children.
Tags: Dyvon