Romilast Tablet 500 mcg

Roflumilast is indicated:

• As add-on therapy to bronchodilator treatment.
• For the maintenance treatment of severe Chronic Obstructive Pulmonary Disease (COPD) associated with chronic bronchitis (i.e. patients with a history of chronic cough and sputum) in adult patients with a history of frequent exacerbations.

Roflumilast should not be used as a rescue medication.

Roflumilast is a phosphodiesterase-4 (PDE-4) inhibitor which, due to its selective inhibition of the PDE4 isoenzyme, has potential antiinflammatory and antimodulatory effects in the pulmonary system. It is thought that the increased levels of intracellular cyclic AMP are responsible for the therapeutic actions of Roflumilast.

The recommended dosage for patients with COPD is one 500 mcg tablet daily, with or without food.