Pen-G Injection 5 lac unit/vial
- Brand:Opsonin Pharma Ltd
- Product Code: Benzyl Penicillin
- Availability: In Stock
-
11.29Tk.
This product has a minimum quantity of 10
Indications
For use in the treatment of severe infections caused by penicillin G-susceptible microorganisms when rapid and high penicillin levels are required such as in the treatment of septicemia, meningitis, pericarditis, endocarditis and severe pneumonia.
Pharmacology
Benzylpenicillin has a bactericidal action against gram positive bacteria, gram negative cocci, some other gram negative cross-linking stage of peptidoglycan production through binding and inactivation of transpeptidases on the inner surface of the bacterial cell membrane thus inhibiting bacterial cell wall synthesis. It is inhibited by penicillinase and other β-lactamases.
Dosage
Adult:
Oral: Susceptible infections: 125-312 mg 4-6 hrly.
IM/IV: Susceptible infections: 0.6-3.6 g/day in 4-6 divided doses.
IV:
Child:
IV: Meningococcal meningitis, Pneumococcal meningitis:
Oral: Susceptible infections: 125-312 mg 4-6 hrly.
IM/IV: Susceptible infections: 0.6-3.6 g/day in 4-6 divided doses.
IV:
- Bacterial endocarditis: 7.2-12 g/day in divided doses.
- Intrapartum prophylaxis against group B Streptoccocal infection in neonates Initial: 3 g, followed by 1.5 g 4 hrly until delivery.
- Meningococcal meningitis; Pneumococcal meningitis: 2.4 g 4 hrly. Max: 18 g/day in meningococcal meningitis.
Child:
IV: Meningococcal meningitis, Pneumococcal meningitis:
- Newborn infants: 100 mg/kg daily in 2 divided doses;
- 1-4 wk: 150 mg/kg daily in 3 divided doses;
- >1 mth to 12 yr: 180-300 mg/kg daily in 4-6 divided doses.
- Newborn infants: 50 mg/kg daily in 2 divided doses;
- 1-4 wk: 75 mg/kg daily in 3 divided doses;
- >1 mth to 12 yr: 100 mg/kg daily in divided doses, not exceeding 4 g/day.
Administration
Should be taken on an empty stomach. Take with a full glass of water on an empty stomach 1 hr before or 2 hr after meals. Do not take acidic beverages within 1 hr of a dose.
Interaction
May increase the risk of methotrexate toxicity. Increased plasma concentration with probenecid. Antagonism of bactericidal effect with bacteriostatic antibacterials (e.g. erythromycin, tetracyclines).
Contraindications
Hypersensitivity to benzylpenicillin and other penicillins.
Side Effects
Nausea, vomiting, stomatitis, black or hairy tongue, rash, fever, serum-like sickness, convulsions, interstitial nephritis, haemolytic anaemia, granulocytopenia, agranulocytosis, leucopenia, thrombocytopenia
Pregnancy & Lactation
Pregnancy category B. Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect that was not confirmed in controlled studies in women in the 1st trimester.
Lactation: Monitor electrolyte, hepatic, renal, cardiac and haematologic function; signs and symptoms of anaphylaxis during 1st dose.
Lactation: Monitor electrolyte, hepatic, renal, cardiac and haematologic function; signs and symptoms of anaphylaxis during 1st dose.
Precautions & Warnings
Patient with history of allergy esp β-lactam allergy and/or asthma, seizure disorder. Diabetic patients. Renal impairment. Pregnancy and lactation.
Overdose Effects
Symptoms: Agitation, confusion, asterixis, hallucinations, stupor, coma, multifocal myoclonus, seizures and encephalopathy, hyperkalaemia.
Management: Symptomatic and supportive treatment.
Management: Symptomatic and supportive treatment.
Therapeutic Class
Benzylpenicillin & Phenoxymethyl penicillin
Reconstitution
Loosen the powder, then, hold the vial horizontally and rotate it while slowly directing the stream of diluent against the wall of the vial. Shake the vial vigorously after all the diluent has been added. Depending on the route of admin, reconstitute with sterile water for inj, NaCl 0.9% inj or dextrose 5% inj.
Storage Conditions
Store between 20-25°C. Reconstituted soln: Store between 2-8°C.