- ildren: 1 tea-spoon daily
For reduction of blood ammonia level:
- Hyper-ammoniemia in hepatopathy: a maximum of 18-30 tea-spoons daily.
- In portal systemic encephalopathy: hourly doses of 6-9 tea-spoons of Lactulose solution may be used to induce the rapid laxation. When the laxative effect has been achieved, the dose may then be reduced.
Interaction
With lactulose, there are no major medication interactions. In misuse, potassium deprivation can amplify the glycosidic action of cardiac glycosides.
Contraindications
Galactose and/or lactose hypersensitivity; galactose-free diet; gastro-cardial symptom complex; possible intestinal obstruction
Side Effect
Flatulence, cramps, and stomach pain may occur at the start of therapy; this is quickly resolved by lowering the dosage. Overdosing might cause diarrhoea. Electrolyte loss is a common side effect of drug usage (primarily potassium).
Pregnancy & Lactation
Lactulose is classified as a pregnancy category B by the US Food and Drug Administration. Lactulose has been shown in studies to have no negative effects. A registered physician must make decisions about usage during pregnancy and breastfeeding.
Precautions & Warnings
Patients who are intolerant to lactulose should be given the sugar with caution. The dose used in the treatment of (pre) coma hepaticum is generally significantly greater, and diabetics should be aware of this.
Therapeutic Class
Osmotic purgatives
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.
Pharmaceutical Name
NIPRO JMI Pharma Ltd.
Tags: Niprolac 200 ml